Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Biodistribution of a positron-emitting suicide inactivator of monoamine oxidase, carbon-11 pargyline, in mice and a rabbit

Journal Article · · J. Nucl. Med.; (United States)
OSTI ID:5416140
; ; ; ; ; ; ; ;
Carbon-11 (/sup 11/C) pargyline, which is a suicide inactivator of Type B monoamine oxidase (MAO), was synthesized by the reaction of N-demethylpargyline with /sup 11/CH/sub 3/l. Biodistribution was investigated in mice, and positron tomographic images of the heart and lung in a rabbit were obtained. The distribution of /sup 11/C after administration of (/sup 11/C)pargyline was measured in several organs and blood at various time intervals. After 30 min its concentrations in the organs were constant. Subcellular distribution studies in the brain, lung, liver, and kidney showed that 59-70% of the /sup 11/C became acid-insoluble and 9-33% was present in the crude mitochondrial fraction at 60 min after injection. The uptakes of the /sup 11/C in each organ except for the kidney and spleen seemed to correlate with the in vitro enzymatic activity of Type B MAO. At high loading dose a nonspecific uptake was observed.
Research Organization:
Tohoku Univ., Sendai, Japan
OSTI ID:
5416140
Journal Information:
J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 26:6; ISSN JNMEA
Country of Publication:
United States
Language:
English

Similar Records

Reye's syndrome: salicylate and mitochondrial monoamine oxidase function
Conference · Fri Feb 28 23:00:00 EST 1986 · Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) · OSTI ID:5390021
Determination of the rate constant for neuronal and extra-neuronal monoamine oxidase
Conference · Fri Feb 28 23:00:00 EST 1986 · Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) · OSTI ID:5451079
MONOAMINE OXIDASE: RADIOTRACER DEVELOPMENT AND HUMAN STUDIES.
Book · Thu Sep 28 00:00:00 EDT 2000 · OSTI ID:767187

Related Subjects

550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AMINE OXIDASES
ANIMALS
ANTIHYPERTENSIVE AGENTS
AUTORADIOGRAPHY
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
BRAIN
CARBON 11
CARBON ISOTOPES
CARDIOVASCULAR AGENTS
CARDIOVASCULAR SYSTEM
CELL CONSTITUENTS
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISTRIBUTION
DRUGS
EMISSION COMPUTED TOMOGRAPHY
ENZYMES
EVEN-ODD NUCLEI
GLANDS
HEART
INACTIVATION
ISOTOPES
KIDNEYS
LIGHT NUCLEI
LIVER
LUNGS
MAMMALS
MICE
MINUTES LIVING RADIOISOTOPES
MITOCHONDRIA
NERVOUS SYSTEM
NUCLEI
ORGANOIDS
ORGANS
OXIDOREDUCTASES
POSITRON COMPUTED TOMOGRAPHY
RABBITS
RADIOISOTOPES
RESPIRATORY SYSTEM
RODENTS
TISSUE DISTRIBUTION
TOMOGRAPHY
VERTEBRATES