MONOAMINE OXIDASE: RADIOTRACER DEVELOPMENT AND HUMAN STUDIES.

Book · Thu Sep 28 04:00:00 EDT 2000

OSTI ID:767187

FOWLER, J S ^[1]; LOGAN, J; VOLKOW, N D; WANG, G J; MACGREGOR, R R; DING, Y S

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1. BROOKHAVEN NATIONAL LABORATORY

PET is uniquely capable of providing information on biochemical transformations in the living human body. Although most of the studies of monoamine oxidase (MAO) have focused on measurements in the brain, the role of peripheral MAO as a phase 1 enzyme for the metabolism of drugs and xenobiotics is gaining attention (Strolin Benedetti and Tipton, 1998; Castagnoli et al., 1997.). MAO is well suited for this role because its concentration in organs such as kidneys, liver and digestive organs is high sometimes exceeding that in the brain. Knowledge of the distribution of the MAO subtypes within different organs and different cells is important in determining which substrates (and which drugs and xenobiotics) have access to which MAO subtypes. The highly variable subtype distribution with different species makes human studies even more important. In addition, the deleterious side effects of combining MAO inhibitors with other drugs and with foodstuffs makes it important to know the MAO inhibitory potency of different drugs both in the brain and in peripheral organs (Ulus et al., 2000). Clearly PET can play a role in answering these questions, in drug research and development and in discovering some of the factors which contribute to the highly variable MAO levels in different individuals.

• Research Organization: Brookhaven National Lab., Upton, NY (US)
• Sponsoring Organization: USDOE Office of Energy Research (ER) (US)
• DOE Contract Number: AC02-98CH10886
• OSTI ID: 767187
• Report Number(s): BNL--67731; KP140102; KP140102
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
DISTRIBUTION
ENZYMES
FOOD
METABOLISM
ORGANS
OXIDOREDUCTASES
SIDE EFFECTS
SUBSTRATES
TRANSFORMATIONS
XENOBIOTICS