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Inflammation-induced synthesis of proteoheparan sulfate: a novel acute-phase reactant in rat hepatocytes

Journal Article · · Inflammation (N.Y.); (United States)
DOI:https://doi.org/10.1007/BF00917770· OSTI ID:6472469
;

The synthesis of proteoheparan sulfate in hepatocytes is positively regulated under acute-phase conditions produced either by turpentine or deep back incision. In both cases the incorporation of (/sup 35/S)sulfate and (/sup 14/C)glucosamine is doubled during a 4-h incubation period if compared with control rat hepatocytes. Neither the fractional secretion rate of heparan sulfate into the medium (less than 0.1 of cell-associated glycosaminoglycans) nor the composition of newly formed proteoglycans in hepatocytes are affected during acute phase reaction.

Research Organization:
Univ. of Marburg, Lahn, Germany, F.R.
OSTI ID:
6472469
Journal Information:
Inflammation (N.Y.); (United States), Journal Name: Inflammation (N.Y.); (United States) Vol. 1; ISSN INFLD
Country of Publication:
United States
Language:
English

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Related Subjects

550901* -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AMINES
ANIMAL CELLS
ANIMALS
ANTICOAGULANTS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOCHEMICAL REACTION KINETICS
CARBOHYDRATES
CARBON 14 COMPOUNDS
DAYS LIVING RADIOISOTOPES
DRUGS
EVEN-ODD NUCLEI
GLUCOPROTEINS
GLUCOSAMINE
HEMATOLOGIC AGENTS
HEPARIN
HEXOSAMINES
HEXOSES
INFLAMMATION
ISOTOPE APPLICATIONS
ISOTOPES
KINETICS
LABELLED COMPOUNDS
LIGHT NUCLEI
LIVER CELLS
MAMMALS
MONOSACCHARIDES
MUCOPOLYSACCHARIDES
NUCLEI
ORGANIC COMPOUNDS
ORGANIC SOLVENTS
ORGANIC SULFUR COMPOUNDS
OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
POLYSACCHARIDES
PROTEINS
RADIOISOTOPES
RATS
REACTION KINETICS
RODENTS
SACCHARIDES
SOLVENTS
SOMATIC CELLS
SULFATES
SULFUR 35
SULFUR COMPOUNDS
SULFUR ISOTOPES
SYMPTOMS
TERPENES
TRACER TECHNIQUES
TURPENTINE
VERTEBRATES