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Ethanol inhibits veratridine-stimulated sodium uptake in synaptosomes

Journal Article · · Life Sci.; (United States)
;
The effects of ethanol and pentobarbital on voltage-sensitive sodium channels in whole brain (rat) synaptosomes were studied using isotopic flux measurements. Incubation of synaptosomes with ethanol or pentobarbitalin vitro inhibited veratridine-stimulated /sup 22/Na/sup +/ uptake. The effect of ethanol is dose-dependent, occurs at sublethal, pharmacologically relevant concentrations and is fully reversible. These results suggest that ethanol and pentobarbital directly interfere with sodium channel function in nervous tissue.
Research Organization:
Armed Forces Radiobiology Research Inst., Bethesda, MD
OSTI ID:
6471962
Journal Information:
Life Sci.; (United States), Journal Name: Life Sci.; (United States) Vol. 34:3; ISSN LIFSA
Country of Publication:
United States
Language:
English

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ALCOHOLS
ALKALI METAL ISOTOPES
ANESTHETICS
ANIMAL CELLS
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
AZINES
BARBITURATES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM DEPRESSANTS
DRUGS
ETHANOL
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
HYPNOTICS AND SEDATIVES
IN VITRO
ISOTOPES
LIGHT NUCLEI
MAMMALS
MEMBRANE TRANSPORT
NEMBUTAL
NERVE CELLS
NERVOUS SYSTEM
NEUROREGULATORS
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
PYRIMIDINES
RADIOISOTOPES
RATS
RECEPTORS
RODENTS
SODIUM 22
SODIUM ISOTOPES
SOMATIC CELLS
VERTEBRATES
YEARS LIVING RADIOISOTOPES