Pulmonary metabolism of dibenz(a,j)acridine: A carcinogenic heterocyclic aromatic: Final report for period September 1, 1982-June 30, 1986

Technical Report · Wed Jul 01 04:00:00 EDT 1987

OSTI ID:6470799

Warshawsky, D

The metabolism of the carcinogenic N-heterocyclic aromatic, dibenz(a,j)-acridine (DBA) was investigated in the isolated perfused lung (IPL) preparation. A significantly increased rate of metabolism was observed for DBA in benzo(a)-pyrene (BaP) and DBA-pretreated animals. This resulted in marked increases in conjugation, in particular sulfates and thioethers, and the distribution of conjugates and total metabolites in blood and lung. When Fe/sub 2/O/sub 3/ was coadministered with DBA to the IPL, the rate of metabolism was significantly decreased with respect to control experiments. This resulted in increased distributions of sulfate and thioether conjugates in blood. Spectroscopic analyses and microsomal enzyme analyses were used in the characterization of the four metabolites identified in the lung. The major nonconjugated metabolite was the 3,4 dihydrodiol of DBA and the three minor metabolites were the 4 and 3 phenol of DBA and a dihydroxy compound of DBA. The results indicate that in the lung DBA is metabolized in a manner similar to that of BaP but different from that of dibenzo-(c,g)carbazole. It is, therefore, apparent that the metabolism of N-heterocyclic aromatics are related to the aromaticity of the heteroatom-containing ring and the solubility of compound, as well as the specific enzymes responsible for activation of the compound. 115 refs., 78 figs., 24 tabs.

• Research Organization: Cincinnati Univ., OH (USA). Dept. of Environmental Health
• DOE Contract Number: AC02-82ER60076
• OSTI ID: 6470799
• Report Number(s): DOE/ER/60076-3; ON: DE87012995
• Country of Publication: United States
• Language: English

Related Subjects

550501 -- Metabolism-- Tracer Techniques
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACRIDINES
ANIMALS
AROMATICS
AZAARENES
AZINES
BODY
CARBON 14 COMPOUNDS
CHALCOGENIDES
CHROMATOGRAPHY
DOCUMENT TYPES
DOSE-RESPONSE RELATIONSHIPS
EMISSION SPECTROSCOPY
FLUORESCENCE SPECTROSCOPY
GLUCURONIDE CONJUGATES
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INJECTION
INTAKE
INTRATRACHEAL ADMINISTRATION
INTRAVENOUS INJECTION
IRON COMPOUNDS
IRON OXIDES
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LIQUID COLUMN CHROMATOGRAPHY
LUNGS
MAMMALS
MASS SPECTROSCOPY
METABOLIC ACTIVATION
METABOLISM
METABOLITES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXIDES
OXYGEN COMPOUNDS
PHENOLS
PYRIDINES
RABBITS
RESPIRATORY SYSTEM
REVIEWS
SEPARATION PROCESSES
SPECTROSCOPY
SULFATES
SULFUR COMPOUNDS
TRACER TECHNIQUES
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES