Growth of an enveloped mycoplasmavirus and establishment of a carrier state
Journal Article
·
· J. Virol.; (United States)
OSTI ID:6470089
The growth of an enveloped DNA-containing mycoplasmavirus (MVL2 obtained from R. N. Gourlay) has been studied, by using the indicator host Acholeplasma laidlawii strain JA1. From virus one-step growth curves, artificial lysis experiments, and infected cell growth curves, it was found that virus infection is nonlytic. Newly infected cells grow slower and are osmotically more stable than uninfected cells. However, 4 to 6 h after infection, the cells reach a carrier state in which cell growth rate and osmotic fragility are indistinguishable from uninfected cells. Carrier cultures contain free virus. Every carrier culture cell gives rise to either a clone of carrier cells or a clone of MVL2-resistant cells.
- Research Organization:
- Univ. of Rochester, NY
- OSTI ID:
- 6470089
- Journal Information:
- J. Virol.; (United States), Journal Name: J. Virol.; (United States) Vol. 22:2; ISSN JOVIA
- Country of Publication:
- United States
- Language:
- English
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