Synthesis of (3-pyridyl)glyoxylic acid derivatives and their antimicrobial properties
Journal Article
·
· Pharmaceut. Chem. J.; (United States)
OSTI ID:6469603
The authors carry out a comparative study of chemical and biological characteristics of the structurally related compounds of several heteroarylglyoxylic acids to determine the influence of the heteroaromatic and, in particular, the basic pyridine ring on the properties of the alpha-oxo-acids. The authors synthesize (3-pyridyl)glyoxylic acid and study its chemical transformations. The structure of many of the compounds was confirmed by the /sup 1/H NMR spectra, and in the case of oxime the signals of the isomers were assigned on the basis of the /sup 13/C NMR spectrum of this compound, containing a /sup 15/N atom in the NOH group.
- Research Organization:
- S. Ordzhonikidze All-Union Scientific-Research Chemico-Pharmaceutical Institute, Moscow (USSR)
- OSTI ID:
- 6469603
- Journal Information:
- Pharmaceut. Chem. J.; (United States), Journal Name: Pharmaceut. Chem. J.; (United States) Vol. 20:5; ISSN PCJOA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550500* -- Metabolism
59 BASIC BIOLOGICAL SCIENCES
640302 -- Atomic
Molecular & Chemical Physics-- Atomic & Molecular Properties & Theory
74 ATOMIC AND MOLECULAR PHYSICS
ALDEHYDES
AMINES
ANTI-INFECTIVE AGENTS
ANTIMICROBIAL AGENTS
AZINES
BIOLOGICAL EFFECTS
CARBON 13
CARBON ISOTOPES
CARBOXYLIC ACIDS
COUPLING
COUPLING CONSTANTS
DRUGS
EVEN-ODD NUCLEI
GLYOXYLIC ACID
HETEROCYCLIC COMPOUNDS
HYDROGEN 1
HYDROGEN ISOTOPES
HYDROXY COMPOUNDS
INTERMEDIATE COUPLING
ISOMERS
ISOTOPES
J-J COUPLING
LIGHT NUCLEI
MATERIALS TESTING
NITROGEN 15
NITROGEN ISOTOPES
NMR SPECTRA
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXIMES
PHARMACOLOGY
PYRIDINES
SPECTRA
STABLE ISOTOPES
SYNTHESIS
TESTING
TRIAZINES
59 BASIC BIOLOGICAL SCIENCES
640302 -- Atomic
Molecular & Chemical Physics-- Atomic & Molecular Properties & Theory
74 ATOMIC AND MOLECULAR PHYSICS
ALDEHYDES
AMINES
ANTI-INFECTIVE AGENTS
ANTIMICROBIAL AGENTS
AZINES
BIOLOGICAL EFFECTS
CARBON 13
CARBON ISOTOPES
CARBOXYLIC ACIDS
COUPLING
COUPLING CONSTANTS
DRUGS
EVEN-ODD NUCLEI
GLYOXYLIC ACID
HETEROCYCLIC COMPOUNDS
HYDROGEN 1
HYDROGEN ISOTOPES
HYDROXY COMPOUNDS
INTERMEDIATE COUPLING
ISOMERS
ISOTOPES
J-J COUPLING
LIGHT NUCLEI
MATERIALS TESTING
NITROGEN 15
NITROGEN ISOTOPES
NMR SPECTRA
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXIMES
PHARMACOLOGY
PYRIDINES
SPECTRA
STABLE ISOTOPES
SYNTHESIS
TESTING
TRIAZINES