Synthesis of an indole analog of folic acid
Journal Article
·
· Pharmaceut. Chem. J.; (United States)
OSTI ID:6465655
The authors study the replacement of the p-aminobenzoic acid (PABA) moiety. The authors synthesized an indole analog of folic acid, namely dimethyl N-(5-(2'-amino-4'-oxo-6'-pteridinyl)methylaminoindol-2-yl)glutamate. The physicochemical properties and the chemical shifts in the PMR spectra of the compounds obtained are shown. The examination of the compound for antitumor activity was carried out using rats and mice.
- Research Organization:
- D.I. Mendeleev Moscow Institute of Chemistry and Technology (USSR)
- OSTI ID:
- 6465655
- Journal Information:
- Pharmaceut. Chem. J.; (United States), Journal Name: Pharmaceut. Chem. J.; (United States) Vol. 20:8; ISSN PCJOA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550200* -- Biochemistry
59 BASIC BIOLOGICAL SCIENCES
640302 -- Atomic
Molecular & Chemical Physics-- Atomic & Molecular Properties & Theory
74 ATOMIC AND MOLECULAR PHYSICS
AMINO ACIDS
ANIMALS
ANTINEOPLASTIC DRUGS
AROMATICS
AZAARENES
AZOLES
BIOLOGICAL EFFECTS
CARBOXYLIC ACID ESTERS
CARBOXYLIC ACIDS
CHEMICAL SHIFT
COUPLING
COUPLING CONSTANTS
DISEASES
DRUGS
ESTERS
FOLIC ACID
GLUTAMIC ACID
HEMATINICS
HEMATOLOGIC AGENTS
HEMIC DISEASES
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
IMMUNE SYSTEM DISEASES
INDOLES
INFRARED SPECTRA
INTERMEDIATE COUPLING
J-J COUPLING
LEUKEMIA
MAMMALS
MATERIALS TESTING
MICE
NEOPLASMS
NMR SPECTRA
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PHARMACOLOGY
PTERIDINES
PYRROLES
RODENTS
SPECTRA
STRUCTURAL CHEMICAL ANALYSIS
SYNTHESIS
TESTING
ULTRAVIOLET SPECTRA
VERTEBRATES
VITAMIN B GROUP
VITAMINS
59 BASIC BIOLOGICAL SCIENCES
640302 -- Atomic
Molecular & Chemical Physics-- Atomic & Molecular Properties & Theory
74 ATOMIC AND MOLECULAR PHYSICS
AMINO ACIDS
ANIMALS
ANTINEOPLASTIC DRUGS
AROMATICS
AZAARENES
AZOLES
BIOLOGICAL EFFECTS
CARBOXYLIC ACID ESTERS
CARBOXYLIC ACIDS
CHEMICAL SHIFT
COUPLING
COUPLING CONSTANTS
DISEASES
DRUGS
ESTERS
FOLIC ACID
GLUTAMIC ACID
HEMATINICS
HEMATOLOGIC AGENTS
HEMIC DISEASES
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
IMMUNE SYSTEM DISEASES
INDOLES
INFRARED SPECTRA
INTERMEDIATE COUPLING
J-J COUPLING
LEUKEMIA
MAMMALS
MATERIALS TESTING
MICE
NEOPLASMS
NMR SPECTRA
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PHARMACOLOGY
PTERIDINES
PYRROLES
RODENTS
SPECTRA
STRUCTURAL CHEMICAL ANALYSIS
SYNTHESIS
TESTING
ULTRAVIOLET SPECTRA
VERTEBRATES
VITAMIN B GROUP
VITAMINS