Synthesis of an indole analog of folic acid
Journal Article
·
· Pharmaceut. Chem. J.; (United States)
OSTI ID:6465655
The authors study the replacement of the p-aminobenzoic acid (PABA) moiety. The authors synthesized an indole analog of folic acid, namely dimethyl N-(5-(2'-amino-4'-oxo-6'-pteridinyl)methylaminoindol-2-yl)glutamate. The physicochemical properties and the chemical shifts in the PMR spectra of the compounds obtained are shown. The examination of the compound for antitumor activity was carried out using rats and mice.
- Research Organization:
- D.I. Mendeleev Moscow Institute of Chemistry and Technology (USSR)
- OSTI ID:
- 6465655
- Journal Information:
- Pharmaceut. Chem. J.; (United States), Vol. 20:8; Other Information: Translated from Khimiko-Farmatsevticheski Zhurnal; 20: No. 8, 932-938(Aug 1986)
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
74 ATOMIC AND MOLECULAR PHYSICS
ANTINEOPLASTIC DRUGS
MATERIALS TESTING
CARBOXYLIC ACID ESTERS
BIOLOGICAL EFFECTS
NMR SPECTRA
SYNTHESIS
INDOLES
CHEMICAL SHIFT
COUPLING CONSTANTS
FOLIC ACID
GLUTAMIC ACID
INFRARED SPECTRA
J-J COUPLING
LEUKEMIA
MICE
PHARMACOLOGY
STRUCTURAL CHEMICAL ANALYSIS
ULTRAVIOLET SPECTRA
AMINO ACIDS
ANIMALS
AROMATICS
AZAARENES
AZOLES
CARBOXYLIC ACIDS
COUPLING
DISEASES
DRUGS
ESTERS
HEMATINICS
HEMATOLOGIC AGENTS
HEMIC DISEASES
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
IMMUNE SYSTEM DISEASES
INTERMEDIATE COUPLING
MAMMALS
NEOPLASMS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PTERIDINES
PYRROLES
RODENTS
SPECTRA
TESTING
VERTEBRATES
VITAMIN B GROUP
VITAMINS
550200* - Biochemistry
640302 - Atomic
Molecular & Chemical Physics- Atomic & Molecular Properties & Theory
74 ATOMIC AND MOLECULAR PHYSICS
ANTINEOPLASTIC DRUGS
MATERIALS TESTING
CARBOXYLIC ACID ESTERS
BIOLOGICAL EFFECTS
NMR SPECTRA
SYNTHESIS
INDOLES
CHEMICAL SHIFT
COUPLING CONSTANTS
FOLIC ACID
GLUTAMIC ACID
INFRARED SPECTRA
J-J COUPLING
LEUKEMIA
MICE
PHARMACOLOGY
STRUCTURAL CHEMICAL ANALYSIS
ULTRAVIOLET SPECTRA
AMINO ACIDS
ANIMALS
AROMATICS
AZAARENES
AZOLES
CARBOXYLIC ACIDS
COUPLING
DISEASES
DRUGS
ESTERS
HEMATINICS
HEMATOLOGIC AGENTS
HEMIC DISEASES
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
IMMUNE SYSTEM DISEASES
INTERMEDIATE COUPLING
MAMMALS
NEOPLASMS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PTERIDINES
PYRROLES
RODENTS
SPECTRA
TESTING
VERTEBRATES
VITAMIN B GROUP
VITAMINS
550200* - Biochemistry
640302 - Atomic
Molecular & Chemical Physics- Atomic & Molecular Properties & Theory