Effect of hematocrit and systolic blood pressure on cerebral blood flow in newborn infants

Journal Article · Mon Jun 01 04:00:00 EDT 1987 · J. Cereb. Blood Flow Metab.; (United States)

DOI:https://doi.org/10.1038/jcbfm.1987.66· OSTI ID:6468181

Younkin, D P; Reivich, M; Jaggi, J L; Obrist, W D; Delivoria-Papadopoulos, M

The effects of hematocrit and systolic blood pressure on cerebral blood flow were measured in 15 stable, low birth weight babies. CBF was measured with a modification of the xenon-133 (/sup 133/Xe) clearance technique, which uses an intravenous bolus of /sup 133/Xe, an external chest detector to estimate arterial /sup 133/Xe concentration, eight external cranial detectors to measure cephalic /sup 133/Xe clearance curves, and a two-compartmental analysis of the cephalic /sup 133/Xe clearance curves to estimate CBF. There was a significant inverse correlation between hematocrit and CBF, presumably due to alterations in arterial oxygen content and blood viscosity. Newborn CBF varied independently of systolic blood pressure between 60 and 84 mm Hg, suggesting an intact cerebrovascular autoregulatory mechanism. These results indicate that at least two of the factors that affect newborn animal CBF are operational in human newborns and may have important clinical implications.

• Research Organization: Univ. of Pennsylvania, Philadelphia
• OSTI ID: 6468181
• Journal Information: J. Cereb. Blood Flow Metab.; (United States), Journal Name: J. Cereb. Blood Flow Metab.; (United States) Vol. 3; ISSN JCBMD
• Country of Publication: United States
• Language: English

Related Subjects

551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AGE GROUPS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD COUNT
BLOOD FLOW
BLOOD PRESSURE
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CHILDREN
CLEARANCE
DAYS LIVING RADIOISOTOPES
DYNAMIC FUNCTION STUDIES
EVEN-ODD NUCLEI
HOMEOSTASIS
INFANTS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
NERVOUS SYSTEM
NUCLEI
ORGANS
RADIOISOTOPES
TRACER TECHNIQUES
XENON 133
XENON ISOTOPES