Cerebral blood flow and oxygen consumption in the newborn dog
Journal Article
·
· Am. J. Physiol.; (United States)
OSTI ID:5558285
Cerebral blood flow (CBF), CBF responses to changes in arterial CO/sub 2/ tension, and cerebral metabolic rate for oxygen (CMRO/sub 2/) were measured in newborn dogs, by means of a modification of the Kety and Schmidt technique employing /sup 133/Xe. Mongrel dogs of 1 to 7 days of age were paralyzed and passively ventilated with 70% N/sub 2/O and 30% O/sub 2/. CBF was derived by analysis of paired serial 20-microliter samples of arterial and of cerebral venous blood from the superior sagittal sinus. At an arterial PCO/sub 2/ of 36.9 +- 3.7 Torr and a mean arterial blood pressure of 62 +- 10 Torr, CBF was 23 +- 8 ml/min per 100 g. The arteriovenous oxygen content difference averaged 5.6 vol %, and CMRO/sub 2/ was 1.13 +- 0.30 ml O/sub 2//min per 100 g. CBF increased or decreased by 0.58 ml/min/100 g per Torr change in PCO/sub 2/. Our results suggest that in the newborn, basal CBF and CBF responses to CO/sub 2/ are considerably lower than in the adult and parallel the lower metabolic needs of the newborn brain.
- Research Organization:
- Pennsylvania State Univ., Hershey
- OSTI ID:
- 5558285
- Journal Information:
- Am. J. Physiol.; (United States), Journal Name: Am. J. Physiol.; (United States) Vol. 234:5; ISSN AJPHA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD FLOW
BLOOD PRESSURE
BODY
BRAIN
CARBON COMPOUNDS
CARBON DIOXIDE
CARBON OXIDES
CENTRAL NERVOUS SYSTEM
CHALCOGENIDES
CRYOGENIC FLUIDS
DAYS LIVING RADIOISOTOPES
DOGS
ELEMENTS
EVEN-ODD NUCLEI
FLUIDS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MEASURING METHODS
METABOLISM
NERVOUS SYSTEM
NITROGEN COMPOUNDS
NITROGEN OXIDES
NITROUS OXIDE
NONMETALS
NUCLEI
ORGANS
OXIDES
OXYGEN
OXYGEN COMPOUNDS
PHYSIOLOGY
RADIOISOTOPES
RARE GASES
TRACER TECHNIQUES
UPTAKE
VERTEBRATES
XENON
XENON 133
XENON ISOTOPES
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD FLOW
BLOOD PRESSURE
BODY
BRAIN
CARBON COMPOUNDS
CARBON DIOXIDE
CARBON OXIDES
CENTRAL NERVOUS SYSTEM
CHALCOGENIDES
CRYOGENIC FLUIDS
DAYS LIVING RADIOISOTOPES
DOGS
ELEMENTS
EVEN-ODD NUCLEI
FLUIDS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MEASURING METHODS
METABOLISM
NERVOUS SYSTEM
NITROGEN COMPOUNDS
NITROGEN OXIDES
NITROUS OXIDE
NONMETALS
NUCLEI
ORGANS
OXIDES
OXYGEN
OXYGEN COMPOUNDS
PHYSIOLOGY
RADIOISOTOPES
RARE GASES
TRACER TECHNIQUES
UPTAKE
VERTEBRATES
XENON
XENON 133
XENON ISOTOPES