Cerebral blood flow and metabolism during cardiopulmonary bypass with special reference to effects of hypotension induced by prostacyclin
Cerebral blood flow and metabolism of oxygen, glucose, and lactate were studied in 43 patients undergoing aortocoronary bypass. Twenty-five patients received prostacyclin infusion, 50 ng per kilogram of body weight per minute, during cardiopulmonary bypass (CPB), and 18 patients served as a control group. Regional cerebral blood flow (CBF) was studied by intraarterially injected xenon 133 and a single scintillation detector. Oxygen tension, carbon dioxide tension, oxygen saturation, glucose, and lactate were measured in arterial and cerebral venous blood. Mean arterial blood pressure decreased during hypothermia and prostacyclin infusion to less than 30 mm Hg. The regional CBF was, on average, 22 (standard deviation (SD) 4) ml/100 gm/min before CPB. It increased in the control group during hypothermia to 34 (SD 12) ml/100 gm/min, but decreased in the prostacyclin group to 15 (SD 5) ml/100 gm/min. It increased during rewarming in the prostacyclin group. After CPB, regional CBF was about 40 ml/100 gm/min in both groups. The cerebral arteriovenous oxygen pressure difference decreased more in the control group than in the prostacyclin group during hypothermia. The cerebral metabolic rate of oxygen decreased in both groups from approximately 2 ml/100 gm/min to about 1 ml/100 gm/min during hypothermia, increased again during rewarming, and after CPB was at the levels measured before bypass in both groups. There was no difference between the groups in regard to glucose and lactate metabolism.
- Research Organization:
- Sahlgrenska Sjukhuset, Goeteborg, Sweden
- OSTI ID:
- 5741946
- Journal Information:
- Ann. Thorac. Surg.; (United States), Journal Name: Ann. Thorac. Surg.; (United States) Vol. 4; ISSN ATHSA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Brain hyperperfusion during cardiac operations. Cerebral blood flow measured in man by intra-arterial injection of xenon 133: evidence suggestive of intraoperative microembolism
Cerebral vasoreactivity to carbon dioxide during cardiopulmonary perfusion at normothermia and hypothermia
Related Subjects
550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ALDEHYDES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BLOOD FLOW
BLOOD PRESSURE
BODY
BRAIN
CARBOHYDRATES
CARBON COMPOUNDS
CARBON DIOXIDE
CARBON OXIDES
CARBOXYLIC ACID SALTS
CENTRAL NERVOUS SYSTEM
CHALCOGENIDES
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
ELEMENTS
EVEN-ODD NUCLEI
GLUCOSE
HEXOSES
HYPOTENSION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LACTATES
MEDICINE
METABOLISM
MONOSACCHARIDES
NERVOUS SYSTEM
NONMETALS
NUCLEI
ORGANIC COMPOUNDS
ORGANS
OXIDES
OXYGEN
OXYGEN COMPOUNDS
PATIENTS
PROSTAGLANDINS
RADIOISOTOPE SCANNING
RADIOISOTOPES
SACCHARIDES
SCINTISCANNING
SURGERY
XENON 133
XENON ISOTOPES