Subacute radiation dermatitis: a histologic imitator of acute cutaneous graft-versus-host disease
Journal Article
·
· J. Am. Acad. Dermatol.; (United States)
The histopathologic changes of radiation dermatitis have been classified either as early effects (necrotic keratinocytes, fibrin thrombi, and hemorrhage) or as late effects (vacuolar changes at the dermal-epidermal junction, atypical radiation fibroblasts, and fibrosis). Two patients, one exposed to radiation therapeutically and one accidentally, are described. Skin biopsy specimens showed an interface dermatitis characterized by numerous dyskeratotic epidermal cells with lymphocytes in close apposition (satellite cell necrosis); that is, the epidermal changes were similar to those in acute graft-versus-host disease. Because recipients of bone marrow transplants frequently receive total body irradiation as part of their preparatory regimen, the ability of radiation to cause persistent epidermal changes similar to those in acute graft-versus-host disease could complicate the interpretation of posttransplant skin biopsy specimens.
- Research Organization:
- Univ. of California, San Francisco (USA)
- OSTI ID:
- 6466181
- Journal Information:
- J. Am. Acad. Dermatol.; (United States), Journal Name: J. Am. Acad. Dermatol.; (United States) Vol. 20; ISSN JAADD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DATA COVARIANCES
DERMATITIS
DISEASES
GRAFT-HOST REACTION
INJURIES
LEUKOCYTES
LOCAL RADIATION EFFECTS
LYMPHOCYTES
MATERIALS
MEDICINE
NECROSIS
NUCLEAR MEDICINE
ORGANS
PATHOLOGICAL CHANGES
PATIENTS
RADIATION EFFECTS
RADIATION INJURIES
RADIODERMATITIS
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
SKIN
SKIN DISEASES
SOMATIC CELLS
THERAPY
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DATA COVARIANCES
DERMATITIS
DISEASES
GRAFT-HOST REACTION
INJURIES
LEUKOCYTES
LOCAL RADIATION EFFECTS
LYMPHOCYTES
MATERIALS
MEDICINE
NECROSIS
NUCLEAR MEDICINE
ORGANS
PATHOLOGICAL CHANGES
PATIENTS
RADIATION EFFECTS
RADIATION INJURIES
RADIODERMATITIS
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
SKIN
SKIN DISEASES
SOMATIC CELLS
THERAPY