Synthesis and antibacterial activity of 6- and 7-(furyl-2)-1-ethyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acids

Journal Article · Wed Dec 31 23:00:00 EST 1986 · Pharmaceut. Chem. J.; (United States)

OSTI ID:6464099

Glushkov, R G; Adamskaya, E V; Oleinik, A F; Silin, V A; Padeiskaya, E N; Solov'eva, N P

The authors have synthesized analogs of oxolinic acid in which the structure of the quinoline part of the molecule is unchanged and in which there is a furyl residue at the 6 or 7 position. The structures of several compounds were confirmed by /sup 1/H-NMR spectroscopy and the chemical shifts are given. The antimicrobial activity of the test compounds in liquid media are given, as is the antibacterial activity of furyl-quinolinecarboxylic acids on solid agar medium.

• Research Organization: S. Ordzhonikidze All-Union Chemicopharmaceutical Scientific-Research Institute, Moscow (USSR)
• OSTI ID: 6464099
• Journal Information: Pharmaceut. Chem. J.; (United States), Journal Name: Pharmaceut. Chem. J.; (United States) Vol. 20:3; ISSN PCJOA
• Country of Publication: United States
• Language: English

Related Subjects

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59 BASIC BIOLOGICAL SCIENCES
640302 -- Atomic
Molecular & Chemical Physics-- Atomic & Molecular Properties & Theory
74 ATOMIC AND MOLECULAR PHYSICS
ANTI-INFECTIVE AGENTS
AROMATICS
AZAARENES
AZINES
BACTERIA
BIOLOGICAL EFFECTS
CARBOXYLIC ACID ESTERS
CHEMICAL SHIFT
COUPLING
COUPLING CONSTANTS
DRUGS
ESTERS
FURANS
HETEROCYCLIC COMPOUNDS
HYDROGEN 1
HYDROGEN ISOTOPES
HYPERFINE STRUCTURE
INTERMEDIATE COUPLING
ISOTOPES
J-J COUPLING
LIGHT NUCLEI
MATERIALS TESTING
METABOLISM
MICROORGANISMS
NMR SPECTRA
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PYRIDINES
QUINOLINES
SPECTRA
STABLE ISOTOPES
SYNTHESIS
TESTING