Treatment of cancer of the pancreas by precision high dose (PHD) external photon beam and intraoperative electron beam therapy (IOEBT)

Journal Article · Sun Jan 01 04:00:00 EST 1989 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(89)90031-X· OSTI ID:6462240

Dobelbower, Jr, R R; Howard, J M; Bagne, F R; Eltaki, A; Merrick, III, H W

Twenty-five patients with a diagnosis of unresectable adenocarcinoma of the pancreas were explored in the Clement O. Miniger (COMROC) IOEBT operating amphitheater at the Medical College of Ohio. Seventeen were treated with IOEBT (20-30 Gy, 15 or 18 meV electrons) PHD external beam radiation therapy (40-60 Gy, 1.8 Gy per fraction) plus appropriate operative biliary and gastrointestinal bypass procedures. No intraoperative complications were observed. Two patients died of causes that may have been treatment-related. Two patients developed abdominocutaneous fistulae. Pain was ameliorated in eleven of twelve patients. Jaundice was relieved in all patients. Four of ten patients with weight loss showed a reversal of that trend. Patient survival was not significantly different from that of patients treated with high-dose precision therapy alone.

• Research Organization: Medical College of Ohio, Toledo (USA)
• OSTI ID: 6462240
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 16:1; ISSN IOBPD
• Country of Publication: United States
• Language: English

Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
BEAMS
BODY
CARCINOMAS
DIGESTIVE SYSTEM
DISEASES
ELECTRON BEAMS
ENDOCRINE GLANDS
GLANDS
LEPTON BEAMS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PANCREAS
PARTICLE BEAMS
PATIENTS
PHOTON BEAMS
RADIOLOGY
RADIOTHERAPY
SURVIVAL CURVES
THERAPY