Acute myocardial infarction after heart irradiation in young patients with Hodgkin's disease

Journal Article · Wed Feb 01 04:00:00 EST 1989 · Chest; (United States)

DOI:https://doi.org/10.1378/chest.95.2.388· OSTI ID:6460705

Joensuu, H

Forty-seven patients younger than 40 years at the time of the diagnosis, and irradiated to the mediastinum for Hodgkin's disease at Turku University Central Hospital from 1977 to 1982, were regularly followed for 56 to 127 months after therapy. Two patients developed an acute myocardial infarction ten and 50 months after cardiac irradiation at the age of only 28 and 24 years, respectively. None of the patients died from lymphoma within five years from the diagnosis, but one of the infarctions was eventually fatal. Since acute myocardial infarction is rare in this age group, the result suggests strongly that prior cardiac irradiation is a risk factor for acute myocardial infarction. The possibility of radiation-induced myocardial infarction should be taken into account both in treatment planning and follow-up of patients with Hodgkin's disease.

• Research Organization: Univ. Central Hospital, Turku (Finland)
• OSTI ID: 6460705
• Journal Information: Chest; (United States), Journal Name: Chest; (United States) Vol. 95:2; ISSN CHETB
• Country of Publication: United States
• Language: English

Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BODY
BODY AREAS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CHEST
DISEASES
HEART
HODGKINS DISEASE
IMMUNE SYSTEM DISEASES
LYMPHOMAS
MEDIASTINUM
MEDICINE
MYOCARDIAL INFARCTION
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATIENTS
PLANNING
POST-IRRADIATION EXAMINATION
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
THERAPY