Cloning of cDNA and genomic DNA encoding human type XVIII collagen and localization of the [alpha]1 (XVIII) collagen gene to mouse chromosome 10 and human chromosome 21
- Harvard Medical School, Boston, MA (United States)
- Duke Univ. Medical Center, Durham, NC (United States)
- Children's Hospital/Harvard Medical School, Boston, MA (United States)
Types XV and XVIII collagen belong to a unique and novel subclass of the collagen superfamily for which the authors have proposed the name the MULTIPLEXIN family. Members of this class contain polypeptides with multiple triple-helical domains separated and flanked by non-triple-helical regions. In this paper, they report the isolation of human cDNAs and genomic DNAs encoding the [alpha]1 (XVIII) collagen chain. Utilizing a genomic clone as probe, they have mapped the COL18A1 gene to chromosome 21q22.3 by fluorescence in situ hybridization. In addition, using an interspecific backcross panel, they have shown that the murine Col18a1 locus is on chromosome 10, close to the loci for Col6a1 and Col6a2. 16 refs., 5 figs.
- OSTI ID:
- 6443648
- Journal Information:
- Genomics; (United States), Vol. 19:3; ISSN 0888-7543
- Country of Publication:
- United States
- Language:
- English
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