Extracorporeal irradiation of the blood in a rat model for human acute myelocytic leukemia. Comparative evaluation of three treatment regimens with emphasis on cell compartment analysis
Journal Article
·
· Radiat. Res.; (United States)
Results of three different regimens of extracorporeal irradiation of the blood (ECIB) are compared in a rat model for human acute myelocytic leukemia. The D/sub 0/ for x rays of leukemic cells in the blood was 68 cGy. The transit dose varied from 380 to 660 cGy. Evaluation was performed by follow-up of the number of peripheral leukemic cells and quantitative cell compartment analysis by measuring the distribution of infused /sup 51/Cr-labeled leukemic cells. Repeated sessions of ECIB proved far more effective in terms of cell depletion than one long session. Chromium-51 studies indicated that the sizes of the blood compartments and of the rapidly exchangeable tissue pool are markedly reduced. The more-sessile organ compartments are only slightly influenced. It appeared that the traffic of leukemic cells is subject to a regulatory mechanism. The more the peripheral compartment is depleted, the more cells are mobilized from the rapidly and slowly exchangeable tissue compartments.
- Research Organization:
- Radiobiological Inst., Rijswijk, Netherlands
- OSTI ID:
- 6442425
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 85:3; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560152* -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BIOLOGICAL MODELS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHROMIUM 51
CHROMIUM ISOTOPES
COMPARATIVE EVALUATIONS
DISEASES
DOSES
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
EXTERNAL IRRADIATION
EXTRACORPOREAL IRRADIATION
FRACTIONATED IRRADIATION
HEMIC DISEASES
INTERMEDIATE MASS NUCLEI
IRRADIATION
ISOTOPES
LEUKEMIA
MAMMALS
MATERIALS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
PATIENTS
RADIATION DOSES
RADIOISOTOPES
RADIOLOGY
RADIOSENSITIVITY
RADIOTHERAPY
RATS
RODENTS
THERAPY
VERTEBRATES
560152* -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BIOLOGICAL MODELS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHROMIUM 51
CHROMIUM ISOTOPES
COMPARATIVE EVALUATIONS
DISEASES
DOSES
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
EXTERNAL IRRADIATION
EXTRACORPOREAL IRRADIATION
FRACTIONATED IRRADIATION
HEMIC DISEASES
INTERMEDIATE MASS NUCLEI
IRRADIATION
ISOTOPES
LEUKEMIA
MAMMALS
MATERIALS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
PATIENTS
RADIATION DOSES
RADIOISOTOPES
RADIOLOGY
RADIOSENSITIVITY
RADIOTHERAPY
RATS
RODENTS
THERAPY
VERTEBRATES