Extracorporeal irradiation of the blood in a rate model for human acute myelocytic leukemia: increased efficacy after combination with cell mobilization by low-molecular-weight dextran sulfate

Journal Article · Thu Oct 01 04:00:00 EDT 1981 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3575759· OSTI ID:6027187

Hagenbeek, A; Martens, A C.M.

The efficacy of extracorporeal irradiation of the blood (ECIB) in combination with cell mobilization by dextran sulfate (DS; MW 17,000) was investigated in a rat model for human acute myelocytic leukemia. Repeated injections with DS (q* 3 hr) induced a significant increase in the number of peripheral leukemic cells, i.e., up to 4.5 times the original number 6 hr after the first injection. Cell mobilization in combination with ECIB (2 x 8 hr) caused a depletion of the blood compartments and the rapidly exchangeable tissue pool down to 10 to 25% of their original sizes, as determined by measuring the distribution of infused /sup 51/Cr-labeled leukemic cells and organ weights. These size reductions are about two times as great as those in rats treated with ECIB alone. In addition, the slowly exchangeable tissue pools are significantly depleted when DS is added to ECIB treatment. The reduction the total tumor load was about 50%. This, however, is too small to result in a significant different in survival time between treated and nontreated leukemic rats.

• Research Organization: Radiobiological Institute, Rijswijk, The Netherlands
• OSTI ID: 6027187
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 88:1; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560114* -- Radiation Effects on Biochemicals-- In Animals-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL MODELS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD SUBSTITUTES
BODY FLUIDS
CARBOHYDRATES
CHROMIUM 51
CHROMIUM ISOTOPES
DEXTRAN
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
EXTERNAL IRRADIATION
EXTRACORPOREAL IRRADIATION
HEMATOLOGIC AGENTS
HEMIC DISEASES
INTERMEDIATE MASS NUCLEI
IRRADIATION
ISOTOPES
LEUKEMIA
MAMMALS
MATERIALS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ORGANIC COMPOUNDS
OXYGEN COMPOUNDS
POLYSACCHARIDES
RADIATION EFFECTS
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
RATS
RODENTS
SACCHARIDES
SULFATES
SULFUR COMPOUNDS
THERAPY
TUMOR CELLS
VERTEBRATES