Low resistance junctions between normal and between virus transformed fibroblasts in tissue culture
Journal Article
·
· Exp. Cell Res.; (United States)
- Univ. of California, Berkeley
The occurrence of low resistance junctions between normal chick embryo fibroblasts and between fibroblasts transformed with Rous sarcoma virus in tissue culture was studied with intracellular microelectrodes. The results showed that these junctions were present between normal chick fibroblasts in proliferating cultures as well as between cells in density dependent inhibited cultures. Mechanical injury to a fibroblast within a small group of coupled cells caused the injured fibroblast to uncouple immediately from its neighboring cells without interrupting coupling between the healthy, uninjured cells. In the case of fibroblasts transformed with a Rous sarcoma virus, the results further showed that low resistance junctions were present when the transformation appeared in the infected cells and remained present thereafter.
- OSTI ID:
- 6438280
- Journal Information:
- Exp. Cell Res.; (United States), Journal Name: Exp. Cell Res.; (United States) Vol. 86; ISSN ECREA
- Country of Publication:
- United States
- Language:
- English
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