Physico-chemical methods for the study of polycyclic aromatic hydrocarbon - DNA interactions

Technical Report · Mon Oct 28 00:00:00 EST 1985

OSTI ID:6432694

Geacintov, N E

By studying the reaction rate, intercalative noncovalent binding, and covalent binding of benzo(a)pyrene-7,8-diol-9,10-oxide to different synthetic polynucleotides, a deeper understanding of the reaction mechanisms of aromatic diol epoxide carcinogens with DNA has been obtained. Studies on the structures of the covalent adducts provide a good model for the mechanisms of interaction of these carcinogenic and tumorigenic molecules with DNA. 5 refs., 3 figs.

• Research Organization: New York Univ., NY (USA). Dept. of Chemistry
• DOE Contract Number: AC02-78EV04959
• OSTI ID: 6432694
• Report Number(s): DOE/EV/04959-7; ON: DE86002970
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
DNA ADDUCTS
ABSORPTION SPECTROSCOPY
EPOXIDES
CHEMICAL REACTION KINETICS
OLIGONUCLEOTIDES
CLATHRATES
DICHROISM
EXPERIMENTAL DATA
ULTRAVIOLET SPECTRA
ADDUCTS
DATA
INFORMATION
KINETICS
NUCLEIC ACIDS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
REACTION KINETICS
SPECTRA
SPECTROSCOPY
550200* - Biochemistry
560300 - Chemicals Metabolism & Toxicology