Increased UV resistance of a xeroderma pigmentosum revertant cell line is correlated with selective repair of the transcribed strand of an expressed gene
- Stanford Univ., CA (United States)
People that suffer from xeroderma pigmentosum (XP) are sun sensitive and experience elevated incidences of cancer, particularly skin cancers on sun-light exposed parts of their bodies. Cultured cells from XP patients are found to be subtantially more sensitive to lethal and mutagenic effects of ultraviolet (UV) radiation than are cells from unaffected individuals. Using the cells from XP individuals, researchers study the roles that cyclobutane pyrimidine dimers (CPDs) and 6-4 photoproducts play in UV resistance. The results demonstrate that overall repair measurements can be misleading, and they support the hypothesis that removal of CPDs form the transcribed strands of expressed genes is essential for UV resistance. 36 refs., 5 figs., 1 tab.
- OSTI ID:
- 6432543
- Journal Information:
- Molecular and Cellular Biology; (United States), Vol. 13:2; ISSN 0270-7306
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
ULTRAVIOLET RADIATION
MUTAGENESIS
XP CELLS
RADIOSENSITIVITY
DNA REPAIR
GENE RECOMBINATION
MUTATIONS
XERODERMA PIGMENTOSUM
ANIMAL CELLS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CONGENITAL DISEASES
DISEASES
ELECTROMAGNETIC RADIATION
HEREDITARY DISEASES
RADIATIONS
REPAIR
SKIN DISEASES
560120* - Radiation Effects on Biochemicals
Cells
& Tissue Culture
550200 - Biochemistry