Increased UV resistance of a xeroderma pigmentosum revertant cell line is correlated with selective repair of the transcribed strand of an expressed gene
Journal Article
·
· Molecular and Cellular Biology; (United States)
- Stanford Univ., CA (United States)
People that suffer from xeroderma pigmentosum (XP) are sun sensitive and experience elevated incidences of cancer, particularly skin cancers on sun-light exposed parts of their bodies. Cultured cells from XP patients are found to be subtantially more sensitive to lethal and mutagenic effects of ultraviolet (UV) radiation than are cells from unaffected individuals. Using the cells from XP individuals, researchers study the roles that cyclobutane pyrimidine dimers (CPDs) and 6-4 photoproducts play in UV resistance. The results demonstrate that overall repair measurements can be misleading, and they support the hypothesis that removal of CPDs form the transcribed strands of expressed genes is essential for UV resistance. 36 refs., 5 figs., 1 tab.
- OSTI ID:
- 6432543
- Journal Information:
- Molecular and Cellular Biology; (United States), Journal Name: Molecular and Cellular Biology; (United States) Vol. 13:2; ISSN 0270-7306; ISSN MCEBD4
- Country of Publication:
- United States
- Language:
- English
Similar Records
Repair of DNA in xeroderma pigmentosum conjunctiva. [UV radiation]
Xeroderma pigmentosum: damage to DNA is involved in carcinogenesis. [Studies in cultured human xeroderma pigmentosum cells]
Xeroderma pigmentosum complementation group C cells remove pyrimidine dimers selectively from the transcribed strand of active genes
Journal Article
·
Fri Aug 01 00:00:00 EDT 1975
· Arch. Ophthalmol. (Chicago); (United States)
·
OSTI ID:7282500
Xeroderma pigmentosum: damage to DNA is involved in carcinogenesis. [Studies in cultured human xeroderma pigmentosum cells]
Conference
·
Wed Dec 31 23:00:00 EST 1975
·
OSTI ID:7131121
Xeroderma pigmentosum complementation group C cells remove pyrimidine dimers selectively from the transcribed strand of active genes
Journal Article
·
Thu Aug 01 00:00:00 EDT 1991
· Molecular and Cellular Biology; (United States)
·
OSTI ID:5197686
Related Subjects
550200 -- Biochemistry
560120* -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CONGENITAL DISEASES
DISEASES
DNA REPAIR
ELECTROMAGNETIC RADIATION
GENE RECOMBINATION
HEREDITARY DISEASES
MUTAGENESIS
MUTATIONS
RADIATIONS
RADIOSENSITIVITY
REPAIR
SKIN DISEASES
ULTRAVIOLET RADIATION
XERODERMA PIGMENTOSUM
XP CELLS
560120* -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CONGENITAL DISEASES
DISEASES
DNA REPAIR
ELECTROMAGNETIC RADIATION
GENE RECOMBINATION
HEREDITARY DISEASES
MUTAGENESIS
MUTATIONS
RADIATIONS
RADIOSENSITIVITY
REPAIR
SKIN DISEASES
ULTRAVIOLET RADIATION
XERODERMA PIGMENTOSUM
XP CELLS