Tumor regression and histologic clearance after neutron brachytherapy for bulky localized cervical carcinoma
Journal Article
·
· Cancer (Philadelphia); (United States)
DOI:https://doi.org/10.1002/1097-0142(19821215)50:12<2802::AID-CNCR2820501219>3.0.CO;2-C·
OSTI ID:6430329
The response of bulky, advanced Stage 1B and early Stage II carcinoma of the cervix to neutron brachytherapy (NT and radiotherapy) was studied using combined NT radiation and extrafascial hysterectomy with histologic evaluation. Scheduling of neutron therapy relative to external beam photon therapy, tumor volume, tumor stage, tumor histology, and clinical tumor clearance were assessed in these studied. NT was easily combined with surgery in this study. Low stage tumors, small tumor volume and early neutron implants (scheduled within +/- one week of the start of fractionated radiation) showed more frequent histologic clearance of tumor. Long-term tumor control has been achieved and failures developed distance metastases without pelvic or local recurrence. This experience indicates that NT was effective for tumor clearance and control and represents and promising new modality for localized, advanced tumor therapy.
- Research Organization:
- Radiation Therapy Oncology Center, University of Kentucky Medical Center, Lexington
- OSTI ID:
- 6430329
- Journal Information:
- Cancer (Philadelphia); (United States), Journal Name: Cancer (Philadelphia); (United States) Vol. 50:12; ISSN CANCA
- Country of Publication:
- United States
- Language:
- English
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OSTI ID:6497556
Related Subjects
550603* -- Medicine-- External Radiation in Therapy-- (1980-)
560151 -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARCINOMAS
DISEASES
EVALUATION
FEMALE GENITALS
MEDICINE
NEOPLASMS
NEUTRON THERAPY
NUCLEAR MEDICINE
ORGANS
PATIENTS
RADIATION EFFECTS
RADIOLOGY
RADIOSENSITIVITY
RADIOTHERAPY
THERAPY
TUMOR CELLS
UROGENITAL SYSTEM DISEASES
UTERUS
560151 -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARCINOMAS
DISEASES
EVALUATION
FEMALE GENITALS
MEDICINE
NEOPLASMS
NEUTRON THERAPY
NUCLEAR MEDICINE
ORGANS
PATIENTS
RADIATION EFFECTS
RADIOLOGY
RADIOSENSITIVITY
RADIOTHERAPY
THERAPY
TUMOR CELLS
UROGENITAL SYSTEM DISEASES
UTERUS