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Sensitization or tolerance to Mycobacterium leprae antigen by route of injection

Journal Article · · Infect. Immun.; (United States)
OSTI ID:6429639
; ; ;
Aqueous suspensions of heat-killed Mycobacterium leprae in a dose of 10(7) organisms were highly immunogenic when injected intradermally (i.d.). The same dose of bacteria did not sensitize when given intraperitoneally (i.p.) or intravenously (i.v.), and did so only minimally at best when given subcutaneously. The i.d. route was the most immunogenic for sheep erythrocytes also. M. leprae injected i.p. or i.v. stimulated immune tolerance to M. leprae challenge i.d. In older mice (greater than or equal to 8 weeks), the i.v. injections gave more complete tolerance. Mice that had been rendered tolerant by i.v. injections maintained their tolerance for at least 168 days. Prior UV irradiation of intact mice prevented sensitization by the i.d. route. In normal mice, living M. bovis BCG given i.d. produced good sensitization to M. leprae. Mice that had been made tolerant by i.v. injection of M. leprae could be partially sensitized to M. leprae by i.d. immunization with BCG; mixtures of living BCG and heat-killed M. leprae were no more effective than BCG alone. These findings appear to have relevance to the pathogenesis of lepromatous leprosy and its immunoprophylaxis.
Research Organization:
Leprosy Laboratory, Bacterial Diseases Division, Centers for Disease Control, Atlanta, Georgia
OSTI ID:
6429639
Journal Information:
Infect. Immun.; (United States), Journal Name: Infect. Immun.; (United States) Vol. 38:2; ISSN INFIB
Country of Publication:
United States
Language:
English

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Related Subjects

560134* -- Radiation Effects on Microorganisms-- Vaccine Preparation & Other Applications-- (-1987)
560152 -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANTIGENS
BACTERIA
BACTERIAL DISEASES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
DISEASES
ELECTROMAGNETIC RADIATION
IMMUNE REACTIONS
IMMUNITY
INFECTIOUS DISEASES
INJECTION
INTAKE
LABORATORY ANIMALS
LEPROSY
MICROORGANISMS
MYCOBACTERIUM
PATHOLOGY
RADIATION EFFECTS
RADIATIONS
ULTRAVIOLET RADIATION