Induction of cell-mediated immunity to Mycobacterium leprae in mice
Journal Article
·
· Infect. Immun.; (United States)
OSTI ID:5577897
The immune response of mice to armadillo-derived, irradiation-killed Mycobacterium leprae (I-ML) was investigated. Following injection of 100 microgram of I-ML into the left hind footpads of mice, a state of cell-mediated immunity (CMI) was engendered to antigens of M. leprae. The evidence for CMI was as follows: (1) development of delayed-type hypersensitivity to both human tuberculin purified protein derivative and soluble M. leprae antigens; (2) T-lymphocyte-dependent macrophage activation at the inoculation site; (3) specific systemaic resistance to the cross-reactive species M. tuberculosis; and (4) immunopotentiation of the delayed-type hypersensitivity response to an unrelated antigen. The CMI induced by I-ML in aqueous suspension was greater than that obtained with the same antigen in water-in-oil emulsion, even though the latter generated a more severe reaction at the site of immunization. I-ML also induced a stronger CMI response than the corresponding dose of heat-killed BCG.
- Research Organization:
- Trudeau Inst., Inc., Saranac Lake, NY
- OSTI ID:
- 5577897
- Journal Information:
- Infect. Immun.; (United States), Journal Name: Infect. Immun.; (United States) Vol. 19:1; ISSN INFIB
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550700 -- Microbiology
560134* -- Radiation Effects on Microorganisms-- Vaccine Preparation & Other Applications-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTIGENS
BACTERIA
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CELL KILLING
IMMUNE REACTIONS
IMMUNITY
IRRADIATION
KINETICS
MAMMALS
MICE
MICROORGANISMS
MYCOBACTERIUM
RADIATION EFFECTS
REACTION KINETICS
RODENTS
VACCINES
VERTEBRATES
560134* -- Radiation Effects on Microorganisms-- Vaccine Preparation & Other Applications-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTIGENS
BACTERIA
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CELL KILLING
IMMUNE REACTIONS
IMMUNITY
IRRADIATION
KINETICS
MAMMALS
MICE
MICROORGANISMS
MYCOBACTERIUM
RADIATION EFFECTS
REACTION KINETICS
RODENTS
VACCINES
VERTEBRATES