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Title: Zinc and Chlamydia trachomatis

Abstract

Zinc was noted to have significant effects upon the infection of McCoy cells by each of two strains of Chlamydia trachomatis. With a high or low Chlamydia inoculant, the number of infected cells increased up to 200% utilizing supplemental zinc (up to 1 x 10/sup -4/ M) in the inoculation media compared with standard Chlamydia cultivation media (8 x 10/sup -6/ M zinc). Ferric chloride and calcium chloride did not effect any such changes. Higher concentrations of zinc, after 2 hr of incubation with Chlamydia, significantly decreased the number of inclusions. This direct effect of zinc on the Chlamydia remained constant after further repassage of the Chlamydia without supplemental zinc, suggesting a lethal effect of the zinc. Supplemental zinc (up to 10/sup -4/ M) may prove to be a useful addition to inoculation media to increase the yield of culturing for Chlamydia trachomatis. Similarly, topical or oral zinc preparations used by people may alter their susceptibility to Chamydia trachomatis infections.

Authors:
;
Publication Date:
Research Org.:
VA Medical Center, Houston, TX
OSTI Identifier:
6428150
Alternate Identifier(s):
OSTI ID: 6428150
Resource Type:
Conference
Journal Name:
Proc. Soc. Exp. Biol. Med.; (United States)
Additional Journal Information:
Journal Volume: 179:3; Conference: 85. annual meeting of the American Society for Microbiology, Las Vegas, NV, USA, Mar 1985
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; RICKETTSIAE; INFECTIVITY; ZINC; BIOLOGICAL EFFECTS; TOXICITY; ANIMAL CELLS; DOSE-RESPONSE RELATIONSHIPS; EXPERIMENTAL DATA; GROWTH; SENSITIVITY; DATA; ELEMENTS; INFORMATION; METALS; MICROORGANISMS; NUMERICAL DATA 560302* -- Chemicals Metabolism & Toxicology-- Microorganisms-- (-1987)

Citation Formats

Sugarman, B., and Epps, L.R. Zinc and Chlamydia trachomatis. United States: N. p., 1985. Web.
Sugarman, B., & Epps, L.R. Zinc and Chlamydia trachomatis. United States.
Sugarman, B., and Epps, L.R. Mon . "Zinc and Chlamydia trachomatis". United States.
@article{osti_6428150,
title = {Zinc and Chlamydia trachomatis},
author = {Sugarman, B. and Epps, L.R.},
abstractNote = {Zinc was noted to have significant effects upon the infection of McCoy cells by each of two strains of Chlamydia trachomatis. With a high or low Chlamydia inoculant, the number of infected cells increased up to 200% utilizing supplemental zinc (up to 1 x 10/sup -4/ M) in the inoculation media compared with standard Chlamydia cultivation media (8 x 10/sup -6/ M zinc). Ferric chloride and calcium chloride did not effect any such changes. Higher concentrations of zinc, after 2 hr of incubation with Chlamydia, significantly decreased the number of inclusions. This direct effect of zinc on the Chlamydia remained constant after further repassage of the Chlamydia without supplemental zinc, suggesting a lethal effect of the zinc. Supplemental zinc (up to 10/sup -4/ M) may prove to be a useful addition to inoculation media to increase the yield of culturing for Chlamydia trachomatis. Similarly, topical or oral zinc preparations used by people may alter their susceptibility to Chamydia trachomatis infections.},
doi = {},
journal = {Proc. Soc. Exp. Biol. Med.; (United States)},
number = ,
volume = 179:3,
place = {United States},
year = {1985},
month = {7}
}

Conference:
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