Zinc and Chlamydia trachomatis

Conference · Mon Jul 01 00:00:00 EDT 1985 · Proc. Soc. Exp. Biol. Med.; (United States)

OSTI ID:6428150

Sugarman, B; Epps, L R

Zinc was noted to have significant effects upon the infection of McCoy cells by each of two strains of Chlamydia trachomatis. With a high or low Chlamydia inoculant, the number of infected cells increased up to 200% utilizing supplemental zinc (up to 1 x 10/sup -4/ M) in the inoculation media compared with standard Chlamydia cultivation media (8 x 10/sup -6/ M zinc). Ferric chloride and calcium chloride did not effect any such changes. Higher concentrations of zinc, after 2 hr of incubation with Chlamydia, significantly decreased the number of inclusions. This direct effect of zinc on the Chlamydia remained constant after further repassage of the Chlamydia without supplemental zinc, suggesting a lethal effect of the zinc. Supplemental zinc (up to 10/sup -4/ M) may prove to be a useful addition to inoculation media to increase the yield of culturing for Chlamydia trachomatis. Similarly, topical or oral zinc preparations used by people may alter their susceptibility to Chamydia trachomatis infections.

• Research Organization: VA Medical Center, Houston, TX
• OSTI ID: 6428150
• Journal Information: Proc. Soc. Exp. Biol. Med.; (United States), Vol. 179:3; Conference: 85. annual meeting of the American Society for Microbiology, Las Vegas, NV, USA, Mar 1985
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
RICKETTSIAE
INFECTIVITY
ZINC
BIOLOGICAL EFFECTS
TOXICITY
ANIMAL CELLS
DOSE-RESPONSE RELATIONSHIPS
EXPERIMENTAL DATA
GROWTH
SENSITIVITY
DATA
ELEMENTS
INFORMATION
METALS
MICROORGANISMS
NUMERICAL DATA
560302* - Chemicals Metabolism & Toxicology- Microorganisms- (-1987)