Simple computer quantitation of spleen-to-liver ratios in the diagnosis of hepatocellular disease. [/sup 99m/Tc-sulfur colloid]
Increased splenic uptake of radiocolloids is a helpful sign in the scintigraphic diagnosis of various hepatocellular diseases, but little attempt has been made to quantify this physiologic phenomenon. We have devised a simple computer method that compares average splenic activity to average right-lobe liver activity. The method is reproducible (r = 0.97) and exhibits little interobserver variation (r = 0.99). One hundred clinically normal subjects were found to have a nearly symmetrical distribution of S/L ratios around a mean of 0.77, with a s.d. of 0.20. Fifteen subjects normal by biopsy were found to have a similar mean spleen-to-liver (S/L) ratio of 0.74. Based upon a normal range of 0.37 to 1.17 (0.77 +- 2 s.d.), elevated S/L ratios were found in fatty metamorphosis (85%), cirrhosis (67%), and chronic hepatitis (43%). Abnormal S/L ratios in the range from 1.17 to approximately 1.4 were not visually obvious. Overall sensitivity of the S/L ratio in these three diseases is 69%. When combined with the other scintigrapic indications of hepatocellular disease (nonhomogeneous colloid uptake, hepatomegaly, splenomegaly, and bone-marrow colloidal uptake), the liver scan was found to have a sensitivity of 93%.
- Research Organization:
- Kuakini Medical Center, Honolulu, HI
- OSTI ID:
- 6425486
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 20:2
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
DIGESTIVE SYSTEM DISEASES
DIAGNOSIS
HEPATITIS
LIVER
RADIONUCLIDE KINETICS
SCINTISCANNING
LIVER CIRRHOSIS
RADIOCOLLOIDS
BIOLOGICAL LOCALIZATION
SPLEEN
TECHNETIUM 99
ISOMERIC NUCLEI
PATIENTS
QUANTITY RATIO
SULFUR COMPLEXES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
COLLOIDS
COMPLEXES
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
DISPERSIONS
GLANDS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
TECHNETIUM ISOTOPES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
560171 - Radiation Effects- Nuclide Kinetics & Toxicology- Man- (-1987)