Megavoltage irradiation of epithelial tumors of the nasopharynx

Conference · Wed Apr 01 04:00:00 EST 1981 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

OSTI ID:6422126

Mesic, J B; Fletcher, G H; Goepfert, H

The present analysis is limited to 251 patients treated with megavoltage irradiation at M.D. Anderson Hospital and Tumor Institute between 1954 and December 1977. The 5-year actuarial disease-free survival for all patients studied is 52%; it is 42%, 65%, and 14%, respectively, for those with squamous cell carcinoma, lymphoepithelioma, and unclassified carcinoma. There were 49 local failures, 32 regional failures, and 73 distant metastases. A previous review had shown an unsatisfactory control rate for T/sub 1/ and T/sub 2/ squamous cell carcinoma, the reason for which may have been that the actual delivered dose to the nasopharynx was less than the calculated dose. Since 1972, an additional 500 to 750 rad has been delivered through parallel opposed small fields centered over the angle of the nasopharynx. Thus, this analysis is divided into two periods, 1954 through December 1971, and January 1972 through December 1977, to evaluate the effectiveness of the treatment changes. The control rate for T/sub 1/ and T/sub 2/ squamous cell carcinomas has increased from 76.4% to 94.2%.

• Research Organization: Univ. of Texas System Cancer Center, Houston
• OSTI ID: 6422126
• Conference Information: Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Journal Volume: 7:4
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CENTRAL NERVOUS SYSTEM
DELAYED RADIATION EFFECTS
DIGESTIVE SYSTEM
DISEASES
DOSES
ENDOCRINE GLANDS
EPITHELIUM
EXTERNAL IRRADIATION
FIBROSIS
GLANDS
IRRADIATION
MEDICAL SURVEILLANCE
MEDICINE
MYELITIS
NECROSIS
NEOPLASMS
NERVES
NERVOUS SYSTEM
NERVOUS SYSTEM DISEASES
NUCLEAR MEDICINE
ORGANS
PATHOLOGICAL CHANGES
PATIENTS
PHARYNX
PITUITARY GLAND
RADIATION DOSES
RADIATION EFFECTS
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
RESPIRATORY SYSTEM
SALIVARY GLANDS
SIDE EFFECTS
SPINAL CORD
SURVEILLANCE
SURVIVAL CURVES
THERAPY
TIME DEPENDENCE
TISSUES