Age dependence of the level of the enzymes involved in the protection against active oxygen species in the rat brain

Journal Article · Mon Jun 01 00:00:00 EDT 1987 · Proc. Soc. Exp. Biol. Med.; (United States)

DOI:https://doi.org/10.3181/00379727-185-42526· OSTI ID:6417377

Scarpa, M; Rigo, A; Viglino, P; Stevanato, R; Bracco, F; Battistin, L

Levels of Cu, Zn superoxide dismutase (CuSOD), Mn superoxide dismutase (MnSOD), catalase, and glutathione peroxidase (GPx) were assessed in the rat brain cortex. The concentrations of Cu- and MnSOD were found to increase linearly with the logarithm of the age of the animal from 3 days before birth to 30 months, both in the whole cortex tissue and in its cytoplasmic fraction. Catalase and GPx levels showed different trends; in particular, GPx, which appears to play a key role in detoxification of hydrogen peroxide, after an initial fall increases steadily with age. The enhancement of the levels of SOD and GPx could be related to protection against an increased production of reactive oxygen species in the aging process.

• Research Organization: Univ. of Padova, Italy
• OSTI ID: 6417377
• Journal Information: Proc. Soc. Exp. Biol. Med.; (United States), Vol. 185:2
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
HYDROGEN PEROXIDE
DETOXIFICATION
PEROXIDASES
ENZYME ACTIVITY
SUPEROXIDE DISMUTASE
AGE DEPENDENCE
AGING
BRAIN
COPPER
GLUTATHIONE
MANGANESE
RADICALS
RATS
ZINC
ANIMALS
BODY
CENTRAL NERVOUS SYSTEM
DRUGS
ELEMENTS
ENZYMES
HYDROGEN COMPOUNDS
MAMMALS
METALS
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
OXIDOREDUCTASES
OXYGEN COMPOUNDS
PEPTIDES
PEROXIDES
POLYPEPTIDES
PROTEINS
RADIOPROTECTIVE SUBSTANCES
RODENTS
TRANSITION ELEMENTS
VERTEBRATES
550200* - Biochemistry
560300 - Chemicals Metabolism & Toxicology