Influence of copper status on antioxidant defense and lipid peroxidation following chronic ethanol feeding in the rat

Conference · Mon Mar 11 04:00:00 EST 1991 · FASEB Journal (Federation of American Societies for Experimental Biology); (United States)

OSTI ID:5264967

Greco, D J; Zidenberg-Cherr, S; Han, B; Rosenbaum, J; Keen, C L ^[1]

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1. Univ. of California, Davis (United States)

The effects of chronic ethanol (Et) consumption on liver antioxidant defense and lipid peroxidation were assessed in Cu sufficient (+Cu) and deficient ({minus}Cu) rats fed liquid diets with Et or dextrose (C) at 36% of kcals for 2 mo. Rats in the Et groups consumed less calories than those in the non-Et groups, thus a restricted intake group (RI) was included to account for any effects due to caloric restriction. Et feeding resulted in lower Cu and Zn and higher Mn concentrations in +Cu and {minus}Cu rats relative to C rats. Both Cu intake and Et resulted in lower CuZn superoxide dismutase (CuSOD) and glutathione peroxidase activities relative to C rats. CuZnSOD and GPx activities were lowest in {minus}CuEt rats; values were 50% of C values. In contrast, Et feeding resulted in higher MnSOD activity in +Cu and {minus}Cu rats. Despite a limited antioxidant defense system in the {minus}Cu rats, Et had no effect on mitochondrial lipid peroxidation as assessed by thiobarbituric acid reacting substances (TBARS). In contrast, microsomal TBRS production was lower in the Et fed groups; the lowest values occurring in the {minus}CuEt rats. These results suggest that in the Cu deficient animal, despite reductions in some components of the antioxidant defense system, compensatory mechanisms can arise which result in a reduction in peroxidation targets and/or an increase in alternate free radical quenching factors.

• OSTI ID: 5264967
• Report Number(s): CONF-9104107--
• Conference Information: Journal Name: FASEB Journal (Federation of American Societies for Experimental Biology); (United States) Journal Volume: 5:4
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALCOHOLS
ANIMALS
BIOLOGICAL EFFECTS
BODY
CELL CONSTITUENTS
CHRONIC EXPOSURE
COPPER
DIGESTIVE SYSTEM
DRUGS
ELEMENTS
ENZYME ACTIVITY
ENZYMES
ETHANOL
GLANDS
GLUTATHIONE
HYDROXY COMPOUNDS
LIPIDS
LIVER
MAMMALS
METABOLISM
METALS
MICROSOMES
MITOCHONDRIA
NUTRITIONAL DEFICIENCY
ORGANIC COMPOUNDS
ORGANS
OXIDOREDUCTASES
PEPTIDES
PEROXIDASES
POLYPEPTIDES
PROTEINS
RADIOPROTECTIVE SUBSTANCES
RATS
RIBOSOMES
RODENTS
SUPEROXIDE DISMUTASE
TRANSITION ELEMENTS
VERTEBRATES