Vasoactive intestinal peptide may participate in the vasodilation of the dog hepatic artery
Journal Article
·
· Am. J. Physiol.; (United States)
OSTI ID:6415800
The possible direct action of vasoactive intestinal peptide (VIP) on dog hepatic arterial wall or on the noradrenergic innervation of the artery was investigated in vitro. In addition, VIP-containing nerve fibers and terminals were located in the wall of the artery with immunochemical staining. Direct evidence showed that VIP did not affect the release of (TH)norepinephrine but reduced the response of the isolated hepatic artery to electrical field stimulation and exogenous norepinephrine. This suggest that the effect of VIP is postjunctional on the smooth muscle of the artery. VIP-containing nerve fibers and varicosities were observed in the adventitial and medial layer of the arterial wall. These findings strongly support the hypothesis that vasoactive intestinal peptide is a physiological mediator of vasodilation in the hepatic artery.
- Research Organization:
- Hungarian Academy of Sciences, Budapest
- OSTI ID:
- 6415800
- Journal Information:
- Am. J. Physiol.; (United States), Journal Name: Am. J. Physiol.; (United States) Vol. 251:2; ISSN AJPHA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ADRENAL HORMONES
ANIMALS
ARTERIES
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOCHEMISTRY
BLOOD VESSELS
BODY
CARDIOTONICS
CARDIOVASCULAR AGENTS
CARDIOVASCULAR SYSTEM
CHEMISTRY
COUNTING TECHNIQUES
CYTOCHEMISTRY
DIGESTIVE SYSTEM
DOGS
DRUGS
GASTROINTESTINAL TRACT
GLANDS
HORMONES
LABELLED COMPOUNDS
LIVER
MAMMALS
NERVES
NERVOUS SYSTEM
NEUROREGULATORS
NORADRENALINE
ORGANIC COMPOUNDS
ORGANS
PEPTIDES
PROTEINS
SCINTILLATION COUNTING
SECRETION
STEROID HORMONES
SYMPATHOMIMETICS
TRITIUM COMPOUNDS
VASODILATION
VASODILATORS
VERTEBRATES
59 BASIC BIOLOGICAL SCIENCES
ADRENAL HORMONES
ANIMALS
ARTERIES
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOCHEMISTRY
BLOOD VESSELS
BODY
CARDIOTONICS
CARDIOVASCULAR AGENTS
CARDIOVASCULAR SYSTEM
CHEMISTRY
COUNTING TECHNIQUES
CYTOCHEMISTRY
DIGESTIVE SYSTEM
DOGS
DRUGS
GASTROINTESTINAL TRACT
GLANDS
HORMONES
LABELLED COMPOUNDS
LIVER
MAMMALS
NERVES
NERVOUS SYSTEM
NEUROREGULATORS
NORADRENALINE
ORGANIC COMPOUNDS
ORGANS
PEPTIDES
PROTEINS
SCINTILLATION COUNTING
SECRETION
STEROID HORMONES
SYMPATHOMIMETICS
TRITIUM COMPOUNDS
VASODILATION
VASODILATORS
VERTEBRATES