Pharmacological characterization of the receptors mediating vasoactive intestinal peptide-induced vasodilation in rat aorta

Conference · Fri Feb 28 23:00:00 EST 1986 · Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)

OSTI ID:5416486

Turner, J T; Bylund, D B

Vasoactive intestinal peptide (VIP)-contain nerve fibers associated with blood vessels are widely distributed, both in the central nervous system and in the periphery. VIP has been shown to be a potent vasodilator in a variety of vascular preparations. The authors have evaluated VIP, the VIP fragment 10-28, and several related peptides including PHI-27, PHM-27 and secretin in terms of their potencies in (1) stimulating the synthesis of cyclic AMP, using the method of Shimizu, in aortic rings; and (2) reversing norepinephrine induced contraction in aortic rings. The authors results indicate that VIP is the most potent of the peptides in both experimental protocols and that the rank order potencies of the various peptides are consistent between the two parameters measured. The authors are currently conducting radioligand binding studies with (/sup 125/I)VIP to further characterize the receptors involved. Additionally, the authors experiments in rat aorta indicate that the presence of the endothelial layer is not required for VIP receptor mediated effects to occur. A potential role for synthetic compounds with high specificity for the VIP receptor in treating hypertension is suggested.

• Research Organization: Univ. of Missouri, Columbia
• OSTI ID: 5416486
• Report Number(s): CONF-8604222-
• Journal Information: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States), Journal Name: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) Vol. 45:3; ISSN FEPRA
• Country of Publication: United States
• Language: English

Related Subjects

550901* -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AMP
AORTA
ARTERIES
BETA DECAY RADIOISOTOPES
BIOCHEMICAL REACTION KINETICS
BLOOD VESSELS
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CHEMICAL COMPOSITION
CONTRACTION
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
GASTROINTESTINAL TRACT
HYPERTENSION
INTERMEDIATE MASS NUCLEI
INTESTINES
IODINE 125
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
KINETICS
LIGANDS
MEMBRANE PROTEINS
MUSCLES
NUCLEI
NUCLEOTIDES
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
PEPTIDES
PROTEINS
RADIOISOTOPES
REACTION KINETICS
RECEPTORS
SYMPTOMS
TRACER TECHNIQUES
VASCULAR DISEASES
VASODILATION