Accelerator mass spectrometry as a bioanalytical tool for nutritional research

Conference · Mon Sep 01 00:00:00 EDT 1997

OSTI ID:641336

Vogel, J S; Turteltaub, K W

Accelerator Mass Spectrometry is a mass spectrometric method of detecting long-lived radioisotopes without regard to their decay products or half-life. The technique is normally applied to geochronology, but recently has been developed for bioanalytical tracing. AMS detects isotope concentrations to parts per quadrillion, quantifying labeled biochemicals to attomole levels in milligram- sized samples. Its advantages over non-isotopeic and stable isotope labeling methods are reviewed and examples of analytical integrity, sensitivity, specificity, and applicability are provided.

• Research Organization: Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
• Sponsoring Organization: USDOE, Washington, DC (United States)
• DOE Contract Number: W-7405-ENG-48
• OSTI ID: 641336
• Report Number(s): UCRL-JC-128472; CONF-9708169-; ON: DE98053185; BR: DP0402061; CNN: W-7405-Eng-48
• Resource Relation: Conference: 6. international conference on nutrition and modeling, Davis, CA (United States), 11-14 Aug 1997; Other Information: PBD: 1 Sep 1997
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
CARBON 14 COMPOUNDS
MASS SPECTROSCOPY
NUTRITIONAL DEFICIENCY
LIQUID COLUMN CHROMATOGRAPHY
TRACER TECHNIQUES
RATS