Accelerator mass spectrometry in biomedical research
Biological effects occur in natural systems at chemical concentrations of parts per billion (1:10{sup 9}) or less. Affected biomolecules may be separable in only milligram or microgram quantities. Quantification at attomole sensitivity is needed to study these interactions. AMS measures isotope concentrations to parts per 10{sup 13--15} on milligram-sized samples and is ideal for quantifying long-lived radioisotopic labels that are commonly used to trace biochemical pathways in natural systems. {sup 14}C-AMS has now been coupled to a variety of organic separation and definition technologies. The primary research investigates pharmacokinetics and genotoxicities of toxins and drugs at very low doses. Human subject research using AMS includes nutrition, toxicity and elemental balance studies. {sup 3} H, {sup 41}Ca and {sup 26}Al are also traced by AMS for fundamental biochemical kinetic research. Expansion of biomedical AMS awaits further development of biochemical and accelerator technologies designed specifically for these applications.
- Research Organization:
- Lawrence Livermore National Lab., CA (United States)
- Sponsoring Organization:
- USDOE, Washington, DC (United States)
- DOE Contract Number:
- W-7405-ENG-48
- OSTI ID:
- 10108632
- Report Number(s):
- UCRL-JC-113838; CONF-930960-4; ON: DE94004336; TRN: 94:001476
- Resource Relation:
- Conference: 6. international conference on accelerator mass spectrometry,Canberra (Australia),17 Sep - 1 Oct 1993; Other Information: PBD: 20 Oct 1993
- Country of Publication:
- United States
- Language:
- English
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