The impact of AMS in biomedical research: A biomedical scientists perspective
- Lawrence Livermore National Lab., CA (United States)
Radioisotope tracing has long been an important means of determining various parameters of biological significance. AMS is a technique well suited for tracing {sup 14}C and other isotopes ({sup 41}Ca, {sup 26}AI, {sup 3}H, {sup 36}Cl, {sup 129}I) through biological systems at levels between 10{sup 3}-10{sup 6}-fold lower than decay counting can achieve. The author has been applying accelerator mass spectrometry (AMS), to tracing isotopically-labeled chemicals in toxicological and pharmacological research for the past 7 years. In toxicology and pharmacology, AMS can play a major role in determining the consequences of exposure to chemicals at very low doses, in understanding mechanisms of action, and in assessing the dosimetric relationships between high-dose animal studies and the very low dose exposures more typical for humans. In addition, AMS is being used as an isotope detector in combination with biochemical separation methods giving attomole sensitivity for following specific molecules. AMS can also be applied in human subjects studies. The ability to detect specific molecules at attomoles levels will have a major impact in defining the risks chemical pose to human health. However, widespread use of this technique by the biomedical research community will depend on the availability of small, inexpensive, instruments.
- DOE Contract Number:
- W-7405-ENG-48
- OSTI ID:
- 199533
- Report Number(s):
- CONF-941129-; CNN: Grant CA55861-01; Grant ES04705-07; TRN: 95:005652-0021
- Resource Relation:
- Conference: 13. international conference on the application of accelerators in research and industry, Denton, TX (United States), 7-10 Nov 1994; Other Information: PBD: 1994; Related Information: Is Part Of Thirteenth international conference on the application of accelerators in research and industry; Duggan, J.L.; Morgan, I.L. [eds.]; PB: 201 p.
- Country of Publication:
- United States
- Language:
- English
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