Role of suppressed hepatocellular regeneration and Ca/sup 2 +/ in chlordecone-potentiated CCl/sub 4/ hepatotoxicity
Thesis/Dissertation
·
OSTI ID:6411340
The mechanism by which the chlorinated pesticide chlordecone (CD; Kepone) potentiates CCl/sub 4/-induced hepatotoxicity and lethality was investigated. It was hypothesized that perturbations in Ca/sup 2 +/ homeostasis, greater than those observed with a low dose of CCl/sub 4/ alone, in concert with a suppression of hepatocellular regeneration induced by CD alone or by CD + CCl/sub 4/ are responsible, at least in part, for CD-potentiated CCl/sub 4/ hepatotoxicity. Ca/sup 2 +/ homeostasis was evaluated by measuring total cell Ca/sup 2 +/ and /sup 45/Ca/sup 2 +/ uptake in viable isolated hepatocyte suspension obtained from normal and CD-pretreated rats receiving CCl/sub 4/ in vivo. In the normal rats in vivo CCL challenge did not affect /sup 45/Ca/sup 2 +/ uptake by viable isolated hepatocytes. In contrast, /sup 45/Ca/sup 2 +/ uptake was inhibited in viable isolated hepatocytes obtained from rats exposed to CD + CCl/sub 4/.
- Research Organization:
- Mississippi Univ., Jackson (USA). Medical Center
- OSTI ID:
- 6411340
- Country of Publication:
- United States
- Language:
- English
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·
OSTI ID:5678377
Related Subjects
550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALKALINE EARTH ISOTOPES
ALKALINE EARTH METALS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL FUNCTIONS
BIOLOGICAL RECOVERY
BIOLOGICAL REGENERATION
BODY
CALCIUM
CALCIUM 45
CALCIUM ISOTOPES
CARBON TETRACHLORIDE
CHLORINATED ALIPHATIC HYDROCARBONS
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
ELEMENTS
EVEN-ODD NUCLEI
FUNCTIONS
GLANDS
HALOGENATED ALIPHATIC HYDROCARBONS
HEPATECTOMY
HOMEOSTASIS
INHIBITION
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
LIVER
MAMMALS
MEDICINE
METALS
NUCLEI
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
PESTICIDES
RADIOISOTOPES
RATS
RECOVERY
RODENTS
SURGERY
SYNERGISM
TOXICITY
TRACER TECHNIQUES
VERTEBRATES
59 BASIC BIOLOGICAL SCIENCES
ALKALINE EARTH ISOTOPES
ALKALINE EARTH METALS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL FUNCTIONS
BIOLOGICAL RECOVERY
BIOLOGICAL REGENERATION
BODY
CALCIUM
CALCIUM 45
CALCIUM ISOTOPES
CARBON TETRACHLORIDE
CHLORINATED ALIPHATIC HYDROCARBONS
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
ELEMENTS
EVEN-ODD NUCLEI
FUNCTIONS
GLANDS
HALOGENATED ALIPHATIC HYDROCARBONS
HEPATECTOMY
HOMEOSTASIS
INHIBITION
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
LIVER
MAMMALS
MEDICINE
METALS
NUCLEI
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
PESTICIDES
RADIOISOTOPES
RATS
RECOVERY
RODENTS
SURGERY
SYNERGISM
TOXICITY
TRACER TECHNIQUES
VERTEBRATES