Three-parameter equation describing the uptake of organic compounds by fish

Journal Article · Fri Jun 01 00:00:00 EDT 1984 · Environ. Sci. Technol.; (United States)

DOI:https://doi.org/10.1021/es00124a009· OSTI ID:6410329

MacKay, D; Hughes, A I

A three-parameter equation is derived by using the fugacity concept, which describes the uptake of organic chemicals from water by fish. The equation is successfully applied to two sets of published uptake data, a study of bioconcentration of a series of PCB congeners and a study of narcosis induced by aqueous solutions of n-alkyl esters of p-aminobenzoic acid, both in goldfish. It is shown that the time constant for uptake and clearance is dependent on the chemicals hydrophobicity expressed as the octanol-water partition coefficient, highly hydrophobic chemicals having long equilibration times. This time constant can be broken down into time attributable to water-phase and lipid-phase diffusion-flow processes.

• Research Organization: Univ. of Toronto, Ontario
• OSTI ID: 6410329
• Journal Information: Environ. Sci. Technol.; (United States), Journal Name: Environ. Sci. Technol.; (United States) Vol. 18:6; ISSN ESTHA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
ANIMALS
AQUATIC ORGANISMS
AROMATICS
BIOLOGICAL ACCUMULATION
CARBOXYLIC ACIDS
CHLORINATED AROMATIC HYDROCARBONS
CONTAMINATION
EQUATIONS
FISHES
HALOGENATED AROMATIC HYDROCARBONS
KINETICS
MATHEMATICAL MODELS
ORGANIC ACIDS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
PABA
TOXICITY
UPTAKE
VERTEBRATES