Use of polynomial expressions to describe the bioconcentration of hydrophobic chemicals by fish

Journal Article · Thu Dec 01 04:00:00 EST 1988 · Ecotoxicol. Environ. Saf.; (United States)

DOI:https://doi.org/10.1016/0147-6513(88)90054-1· OSTI ID:6274685

Connell, D W; Hawker, D W

For the bioconcentration of hydrophobic chemicals by fish, relationships have been previously established between uptake rate constants (k1) and the octanol/water partition coefficient (Kow), and also between the clearance rate constant (k2) and Kow. These have been refined and extended on the basis of data for chlorinated hydrocarbons, and closely related compounds including polychlorinated dibenzodioxins, that covered a wider range of hydrophobicity (2.5 less than log Kow less than 9.5). This has allowed the development of new relationships between log Kow and various factors, including the bioconcentration factor (as log KB), equilibrium time (as log teq), and maximum biotic concentration (as log CB), which include extremely hydrophobic compounds previously not taken into account. The shape of the curves generated by these equations are in qualitative agreement with theoretical prediction and are described by polynomial expressions which are generally approximately linear over the more limited range of log Kow values used to develop previous relationships. The influences of factors such as hydrophobicity, aqueous solubility, molecular weight, lipid solubility, and also exposure time were considered. Decreasing lipid solubilities of extremely hydrophobic chemicals were found to result in increasing clearance rate constants, as well decreasing equilibrium times and bioconcentration factors.

• Research Organization: Griffith Univ., Nathan, Queensland (Australia)
• OSTI ID: 6274685
• Journal Information: Ecotoxicol. Environ. Saf.; (United States), Journal Name: Ecotoxicol. Environ. Saf.; (United States) Vol. 16:3; ISSN EESAD
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AQUATIC ORGANISMS
AROMATICS
BIOLOGICAL ACCUMULATION
CHLORINATED AROMATIC HYDROCARBONS
EQUATIONS
FISHES
HALOGENATED AROMATIC HYDROCARBONS
METABOLISM
MOLECULAR WEIGHT
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
POLLUTION
SENSITIVITY
SOLUBILITY
VERTEBRATES
WATER POLLUTION