Regulation of bcl-2 proto-oncogene expression during normal human lymphocyte proliferation

Journal Article · Fri Jun 05 04:00:00 EDT 1987 · Science (Washington, D.C.); (United States)

DOI:https://doi.org/10.1126/science.3495884· OSTI ID:6408985

Reed, J C; Tsujimoto, Y; Alpers, J D; Croce, C M; Nowell, P C

The bcl-2 and c-myc proto-oncogenes are brought into juxtaposition with the immuno-globulin heavy chain locus in particular B-cell lymphomas, resulting in high levels of constitutive accumulation of their messenger RNAs. Precisely how the products of the bcl-2 and c-myc genes contribute to tumorigenesis is unknown, but observations that c-myc expression is rapidly induced in nonneoplastic lymphocytes upon stimulation of proliferation raise the possibility that this proto-oncogene is involved in the control of normal cellular growth. In addition to c-myc, the bcl-2 proto-oncogene also was expressed in normal human B and T lymphocytes after stimulation with appropriate mitogens. Comparison of the regulation of the expression of these proto-oncogenes demonstrated marked differences and provided evidence that, in contrast to c-myc, levels of bcl-2 messenger RNA are regulated primarily though transcriptional mechanisms. 10 references, 3 figures.

• Research Organization: Univ. Pennsylvania, Philadelphia
• OSTI ID: 6408985
• Journal Information: Science (Washington, D.C.); (United States), Journal Name: Science (Washington, D.C.); (United States) Vol. 236; ISSN SCIEA
• Country of Publication: United States
• Language: English

Related Subjects

550400* -- Genetics
550900 -- Pathology
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CELL PROLIFERATION
CONNECTIVE TISSUE CELLS
DISEASES
GENE REGULATION
GENES
LEUKOCYTES
LYMPHOCYTES
LYMPHOMAS
MAMMALS
MAN
MATERIALS
MESSENGER-RNA
NEOPLASMS
NUCLEIC ACIDS
ONCOGENES
ORGANIC COMPOUNDS
PATHOGENESIS
PRIMATES
RNA
SOMATIC CELLS
TRANSCRIPTION
VERTEBRATES