Absorbed dose to the human adrenals from iodomethylnorcholesterol (I-131) NP-59: concise communication
Journal Article
·
· J. Nucl. Med.; (United States)
OSTI ID:6405604
During the past 2 yrs, adrenal uptake percentage values were measured in more than 40 patients, using an external counting technique. They suggest that the absorbed dose to the adrenals is significantly less than the 150 rads/mCi previously estimated using concentration values from animal adrenals. The measured combined uptake percentage for both adrenals ranged from 0.15% to 0.52% in 21 patients without evidence of adrenal disease, with a mean of 0.33% +- 0.1%; also from 0.22% to 1.5% in 22 patients with Cushing's disease, with a mean uptake of 0.78% +- 0.35%. The absorbed dose to the adrenals was estimated to be 25 rads/mCi for patients without evidence of adrenal disease, and 57 rads/mCi for patients with Cushing's disease. Both values are calculated for the respective mean uptake percentages by using the MIRD formalism.
- Research Organization:
- Univ. of Michigan Medical Center, Ann Arbor
- OSTI ID:
- 6405604
- Journal Information:
- J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 20:1; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
Similar Records
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Journal Article
·
Thu Sep 01 00:00:00 EDT 1977
· J. Nucl. Med.; (United States)
·
OSTI ID:5333254
Adrenal scanning and uptake with /sup 131/1-6. beta. -iodomethyl-nor-cholesterol
Conference
·
Sat Jul 01 00:00:00 EDT 1978
· Radiology; (United States)
·
OSTI ID:6740786
Failure to visualize adrenal glands in a patient with bilateral adrenal hyperplasia. [/sup 131/I]
Journal Article
·
Mon Dec 31 23:00:00 EST 1979
· J. Nucl. Med.; (United States)
·
OSTI ID:5291565
Related Subjects
550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
560161* -- Radionuclide Effects
Kinetics
& Toxicology-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL GLANDS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL LOCALIZATION
BODY
COUNTING TECHNIQUES
CUSHING SYNDROME
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
DOSES
DOSIMETRY
DRUGS
ENDOCRINE DISEASES
ENDOCRINE GLANDS
GLANDS
HYDROXY COMPOUNDS
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
IODINE 131
IODINE ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANS
PATIENTS
RADIATION DOSES
RADIOACTIVE MATERIALS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPHARMACEUTICALS
SCINTISCANNING
STEROIDS
STEROLS
560161* -- Radionuclide Effects
Kinetics
& Toxicology-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL GLANDS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL LOCALIZATION
BODY
COUNTING TECHNIQUES
CUSHING SYNDROME
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
DOSES
DOSIMETRY
DRUGS
ENDOCRINE DISEASES
ENDOCRINE GLANDS
GLANDS
HYDROXY COMPOUNDS
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
IODINE 131
IODINE ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANS
PATIENTS
RADIATION DOSES
RADIOACTIVE MATERIALS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPHARMACEUTICALS
SCINTISCANNING
STEROIDS
STEROLS