Chelation and effectiveness of salicylate related compounds on pyresis, sedimentation rate and hematocrit

Conference · Sun Jan 01 00:00:00 EST 1984

OSTI ID:6405411

Schubert, J; Rosenthal, M W; Fried, J F

The mechanism of action and identification of sites of salicylates and related compounds in antipyresis were studied. Structure-activity investigations of antipyresis were made using Sprague-Dawley rats. Results showed copper was chelated by the salicylate, passes through the cell membrane, and repairs the lesion. 13 references, 2 figures. (ACR)

• Research Organization: Maryland Univ., Catonsville (USA). Dept. of Chemistry; Argonne National Lab., IL (USA)
• DOE Contract Number: W-31-109-ENG-38
• OSTI ID: 6405411
• Report Number(s): CONF-8408105-1; ON: DE84015844
• Resource Relation: Conference: 9. international congress of pharmacology satellite symposium, Pilsen, Czechoslovakia, 6 Aug 1984; Other Information: Portions are illegible in microfiche products
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
SALICYLIC ACID
BIOLOGICAL EFFECTS
ANTIPYRETICS
CATIONS
CHELATES
COPPER
FEVER
RATS
ANIMALS
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
CHARGED PARTICLES
COMPLEXES
DRUGS
ELEMENTS
HYDROXY ACIDS
IONS
MAMMALS
METALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
RODENTS
SYMPTOMS
TRANSITION ELEMENTS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)