Mobility of americium dioxide in the rat. [Clearance (lung, blood, urine) following pulmonary intubation]
The mobility of americium dioxide in the rat after pulmonary intubation was investigated by administering different particle size ranges of fractionated suspensions. The clearance of americium from lungs to blood and urine is governed principally by its ability to form low-molecular-weight complexes, probably hydroxides. Americium is excreted in the urine in greater quantities than that observed following the administration of americium citrate. It is concluded that the metabolic behavior of americium dioxide more closely resembles that of a soluble rather than an insoluble compound. Even so, the systemic burden of americium cannot be predicted by applying a fixed factor to cumulative urinary excretion in the early lung clearance phase.
- Research Organization:
- National Radiological Protection Board, Didcot, Eng.
- OSTI ID:
- 6405325
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 76:3; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE COMPLEXES
ACTINIDE COMPOUNDS
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
AMERICIUM 241
AMERICIUM COMPLEXES
AMERICIUM COMPOUNDS
AMERICIUM ISOTOPES
AMERICIUM OXIDES
ANIMALS
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BIOLOGICAL WASTES
BLOOD-PLASMA CLEARANCE
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BODY FLUIDS
CHALCOGENIDES
CLEARANCE
COMPLEXES
EXCRETION
HEAVY NUCLEI
ISOTOPES
LUNG CLEARANCE
LUNGS
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
OXIDES
OXYGEN COMPOUNDS
PARTICLE SIZE
RADIOISOTOPES
RADIONUCLIDE ADMINISTRATION
RADIONUCLIDE KINETICS
RATS
RESPIRATORY SYSTEM
RODENTS
SIZE
SOLUBILITY
TRANSURANIUM COMPLEXES
TRANSURANIUM COMPOUNDS
URINE
VERTEBRATES
WASTES
YEARS LIVING RADIOISOTOPES