Regional aerosol deposition in human upper airways: Progress report, June 1, 1988--February 28, 1989

Technical Report · Sat Dec 31 23:00:00 EST 1988

OSTI ID:6400115

Swift, D L

The objective of this research program is to elucidate important factors which influence overall and local deposition of aerosols in the human airways above the trachea, including nasal airways, oral passage, pharynx and larynx. The intent is to develop information which can be used for exposure models for radon from unattached radon progeny (/approximately/1nm) up to 10 ..mu..m. Special emphasis is upon flow rate and airway dimensions as influenced by age and respiratory condition, as no experimental data presently exist for age-related deposition. Because of ethical and practical considerations associated with measuring aerosol deposition in children and difficulties of measuring local deposition in vivo, our experimental approach is to construct faithful replicate models of the airways for several ages of humans in which detailed studies of deposition can be carried out with well-characterized aerosols. Initial studies of overall deposition of ultrafine aerosols in an adult model have been carried out using replicate nasal passage models provided from this laboratory. These studies demonstrate a significant deposition percent for particle sizes approaching that of unattached radon progeny (40--50%), decreasing as particle size approaches 0.1 ..mu..m. Studies of the effect of flow rate indicate that higher deposition percent is realized at lower flow rate over the range from 4--60 lmin/sup -1/.

• Research Organization: Johns Hopkins Univ., Baltimore, MD (USA)
• DOE Contract Number: FG02-88ER60655
• OSTI ID: 6400115
• Report Number(s): DOE/ER/60655-1; ON: DE89007095
• Country of Publication: United States
• Language: English

Related Subjects

500200* -- Environment
Atmospheric-- Chemicals Monitoring & Transport-- (-1989)
54 ENVIRONMENTAL SCIENCES
560300 -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
AGE DEPENDENCE
AIR FLOW
AIR POLLUTION
ANIMALS
BIOLOGICAL ACCUMULATION
BIOLOGICAL FUNCTIONS
BODY
COLLOIDS
COMPARATIVE EVALUATIONS
DIGESTIVE SYSTEM
DISPERSIONS
DOCUMENT TYPES
DOSE-RESPONSE RELATIONSHIPS
DOSIMETRY
FLOW RATE
FLUID FLOW
FUNCTIONS
GAS FLOW
HAZARDS
HEALTH HAZARDS
HUMAN POPULATIONS
INHALATION
INTAKE
LUNGS
MAMMALS
MAN
ORGANS
PARTICLE SIZE
PARTICLES
PARTICULATES
PHARYNX
POLLUTANTS
POLLUTION
POPULATIONS
PRIMATES
PROGRESS REPORT
RESPIRATORY SYSTEM
RISK ASSESSMENT
SAMPLING
SIZE
SOLS
SORPTIVE PROPERTIES
SURFACE PROPERTIES
TESTING
VERTEBRATES