Regional aerosol deposition in human upper airways

Technical Report · Thu Nov 01 04:00:00 EST 1990

DOI:https://doi.org/10.2172/6156023· OSTI ID:6156023

Swift, D L

During the current reporting period experimental studies of aerosol deposition in replicate NOPL airways have carried out. A replicate model of a 4 week old infant nasal passage was constructed from MR scans. The model completes the age range from newborn'' to 4 years, there now being one child model for 4 different ages. Deposition studies have been performed with unattached radon progeny aerosols in collaboration with ITRI, Albuquerque, NM and NRPB, Chilton, UK. Overall measurements have been performed in adult and child nasal airways indicating that the child nasal passage was slightly more efficient than the adult in removing 1 nm particles at corresponding flow rates. A similar weak dependence on flow rate was observed. Local deposition studies in an adult nasal model indicated predominant deposition in the anterior region during inspiratory flow, but measurable deposition was found throughout the model. The deposition pattern during expiration was reverse, greater deposition being observed in the posterior region. Local deposition studies of attached progeny aerosol size (100--200 nm) were performed in adult and child nasal models using technigas'' and a gamma scintillation camera. Similar to the unattached size, deposition occurred throughout the models, but was greater in the anterior region.

• Research Organization: Johns Hopkins Univ., Baltimore, MD (USA)
• Sponsoring Organization: DOE/ER
• DOE Contract Number: FG02-88ER60655
• OSTI ID: 6156023
• Report Number(s): DOE/ER/60655-3; ON: DE91002457
• Country of Publication: United States
• Language: English

Related Subjects

54 ENVIRONMENTAL SCIENCES
540130 -- Environment
Atmospheric-- Radioactive Materials Monitoring & Transport-- (1990-)
560161* -- Radionuclide Effects
Kinetics
& Toxicology-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADULTS
AEROSOLS
AGE DEPENDENCE
AGE GROUPS
BIOLOGICAL ACCUMULATION
BODY
CHILDREN
COLLOIDS
CONCENTRATION RATIO
COUNTING TECHNIQUES
DAUGHTER PRODUCTS
DIGESTIVE SYSTEM
DISPERSIONS
DOCUMENT TYPES
DOSE-RESPONSE RELATIONSHIPS
ELEMENTS
FLOW MODELS
FLUIDS
GASES
HAZARDS
HEALTH HAZARDS
INHALATION
INTAKE
ISOTOPES
MATHEMATICAL MODELS
NONMETALS
ORGANS
PARTICLE SIZE
PHARYNX
PROGRESS REPORT
RADIOACTIVE AEROSOLS
RADON
RARE GASES
RESPIRATORY SYSTEM
SCINTILLATION COUNTING
SIZE
SOLS