Regional aerosol deposition in human upper airways

Technical Report · Sun Nov 01 04:00:00 EST 1992

DOI:https://doi.org/10.2172/6967882· OSTI ID:6967882

Swift, D L

Laboratory experimental studies were carried out to investigate the factors influencing the deposition of aerosols ranging in size from 1 nm to 10 [mu]m in the human nasal, oral, pharyngeal and laryngeal airways. These experimental studies were performed in replicate upper airway physical models and in human volunteer subjects. New replicate models of the oral passage of an infant, the oral passage of an adult at two openings and the combined nasal and oral airways of an adult were constructed during the period, adding to the existing models of adult, child and infant nasal and oral airways models. Deposition studies in the adult oral and adult nasal models were performed under simulated cyclic flow conditions with 1 nm particles to compare with previously measured constant flow studies. Similar studies with inertial particles (1--10 [mu]m diameter) were performed with the adult nasal model; in both instances, results with cyclic flow were similar to constant flow results using a simple average flow rate based on inspiratory volume and time of inspiration. Human subject studies were performed with particle sizes 5--20 nm for nasal inspiration; preliminary analysis shows good agreement with model studies at several representative flow rates. Nasal inspiratory inertial deposition of 1--4 [mu]m diameter particles was measured in several adults as a function of airway dimensions; dimensional changes of the valve area by decongestion did not produce concomitant deposition changes.

• Research Organization: Johns Hopkins Univ., Baltimore, MD (United States). School of Hygiene and Public Health
• Sponsoring Organization: DOE; USDOE, Washington, DC (United States)
• DOE Contract Number: FG02-88ER60655
• OSTI ID: 6967882
• Report Number(s): DOE/ER/60655-T1; ON: DE93003882
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADULTS
AEROSOLS
AGE GROUPS
ANIMALS
COLLOIDS
DISPERSIONS
DOCUMENT TYPES
INHALATION
INTAKE
MAMMALS
MAN
MATHEMATICAL MODELS
PARTICLE SIZE
PRIMATES
PROGRESS REPORT
RESPIRATORY SYSTEM
SIZE
SOLS
VERTEBRATES