Preventive central nervous system irradiation in children with acute nonlymphocytic leukemia. [Complications of. gamma. radiation]

Journal Article · Wed Nov 01 04:00:00 EST 1978 · Cancer; (United States)

OSTI ID:6392059

Dahl, G V; Simone, J V; Hustu, H O; Mason, C

In this study of children with acute nonlymphocytic leukemia an attempt was made to prevent central nervous system relapse and to determine whether this therapy, coupled with multiagent chemotherapy, would be successful in prolonging durations of complete remission. Central nervous system relapses were prevented by irradiation, although patients who received this therapy did no better than those who did not receive irradiation. A small group of patients received irradiation to the liver and spleen, but this modality also failed to improve the duration of remission. Control of extramedullary leukemia, in this study, failed to improve remission duration because bone marrow relapse was not prevented or delayed. It is unlikely that focal therapy will have a significant impact in acute nonlymphocytic leukemia until longer marrow remissions are achieved.

• Research Organization: St. Jude Children's Hospital, Memphis, TN
• OSTI ID: 6392059
• Journal Information: Cancer; (United States), Journal Name: Cancer; (United States) Vol. 42:5; ISSN CANCA
• Country of Publication: United States
• Language: English

Related Subjects

560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANEMIAS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CENTRAL NERVOUS SYSTEM
CHEMOTHERAPY
CHILDREN
COBALT 60
COBALT ISOTOPES
DIGESTIVE SYSTEM
DISEASES
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
GAMMA RADIATION
HEMIC DISEASES
HERPES ZOSTER
IMMUNITY
INFECTIOUS DISEASES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LEUKEMIA
LEUKOCYTES
LEUKOPENIA
LOCAL IRRADIATION
MAMMALS
MAN
MEDICINE
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NERVOUS SYSTEM
NEUTROPHILS
NUCLEAR MEDICINE
NUCLEI
ODD-ODD NUCLEI
ORAL CAVITY
ORGANS
PARTIAL BODY IRRADIATION
PATHOLOGICAL CHANGES
PATIENTS
PREVENTIVE MEDICINE
PRIMATES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
SKELETON
SKULL
SPINAL CORD
SYMPTOMS
THERAPY
TOLERANCE
ULCERS
VERTEBRATES
YEARS LIVING RADIOISOTOPES