The effects of prophylactic treatment of the central nervous system on the intellectual functioning of children with acute lymphocytic leukemia
Journal Article
·
· Am. J. Med.; (United States)
The effect of central nervous system prophylaxis (cranial radiation and intrathecal chemotherapy) on intellectual function was studied in 24 children with acute lymphocytic leukemia. The Wechsler Intelligence tests were administered to these children and to a sample of their healthy siblings, who served as a comparison group. The mean Full Scale lQ was 98.6 for the patients and 112.5 for the sibling controls (p less than 0.001 level). Those patients who received central nervous system preventive treatment at a young age exhibited a greater decrement in intellectual abilities than did patients who were older when they received this treatment. In contrast, leukemia patients who had not received central nervous system prophylaxis had IQs that did not differ statistically from those of their siblings. These data suggest that central nervous system prophylaxis may have an adverse effect on the intellectual capability of children with acute lymphocytic leukemia.
- OSTI ID:
- 5282646
- Journal Information:
- Am. J. Med.; (United States), Journal Name: Am. J. Med.; (United States) Vol. 71:1; ISSN AJMEA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Neuropsychological sequelae of central nervous system prophylaxis in survivors of childhood acute lymphoblastic leukemia
Treatment of meningeal relapse in childhood acute lymphoblastic leukemia: II. A prospective study of intellectual loss specific to CNS relapse and therapy
Effects of different forms of central nervous system prophylaxis on neuropsychologic function in childhood leukemia
Journal Article
·
Fri Mar 31 23:00:00 EST 1989
· J. Consult. Clin. Psychol.; (United States)
·
OSTI ID:6023216
Treatment of meningeal relapse in childhood acute lymphoblastic leukemia: II. A prospective study of intellectual loss specific to CNS relapse and therapy
Journal Article
·
· American Journal of Pediatric Hematology/Oncology; (USA)
·
OSTI ID:6919826
Effects of different forms of central nervous system prophylaxis on neuropsychologic function in childhood leukemia
Journal Article
·
Fri Nov 30 23:00:00 EST 1984
· J. Clin. Oncol.; (United States)
·
OSTI ID:5832049
Related Subjects
550100 -- Behavioral Biology
550600 -- Medicine
552000 -- Public Health
560151* -- Radiation Effects on Animals-- Man
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
99 GENERAL AND MISCELLANEOUS
AGE GROUPS
ANIMAL CELLS
BEHAVIOR
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY FLUIDS
CENTRAL NERVOUS SYSTEM
CHEMOTHERAPY
CHILDREN
COMPARATIVE EVALUATIONS
CONNECTIVE TISSUE CELLS
DISEASES
HEMIC DISEASES
LEUKEMIA
LEUKOCYTES
LYMPHOCYTES
MATERIALS
MATHEMATICS
MEDICINE
NEOPLASMS
NERVOUS SYSTEM
NUCLEAR MEDICINE
PATIENTS
PREVENTIVE MEDICINE
RADIATION EFFECTS
RADIOLOGY
RADIOTHERAPY
SOMATIC CELLS
STATISTICS
THERAPY
550600 -- Medicine
552000 -- Public Health
560151* -- Radiation Effects on Animals-- Man
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
99 GENERAL AND MISCELLANEOUS
AGE GROUPS
ANIMAL CELLS
BEHAVIOR
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY FLUIDS
CENTRAL NERVOUS SYSTEM
CHEMOTHERAPY
CHILDREN
COMPARATIVE EVALUATIONS
CONNECTIVE TISSUE CELLS
DISEASES
HEMIC DISEASES
LEUKEMIA
LEUKOCYTES
LYMPHOCYTES
MATERIALS
MATHEMATICS
MEDICINE
NEOPLASMS
NERVOUS SYSTEM
NUCLEAR MEDICINE
PATIENTS
PREVENTIVE MEDICINE
RADIATION EFFECTS
RADIOLOGY
RADIOTHERAPY
SOMATIC CELLS
STATISTICS
THERAPY