Contribution of polycyclic aromatic hydrocarbons and polar polycyclic aromatic compounds to the carcinogenic impact of flue gas condensate from coal-fired residential furnaces evaluated by implantation into the rat lung
For identification of the substances chiefly responsible for the carcinogenic action of the emission condensate from coal-fired residential furnaces, the implantation method was used as a carcinogen-specific bioassay for comparison of the carcinogenic effect of various fractions with that of a total sample of flue gas condensate tested in 2 or 3 different doses. After implantation into the lungs of Osborne-Mendel rats, the condensate from coal-fired residential furnaces, a fraction containing polycyclic aromatic hydrocarbons (PAHs) and thiaarenes (sulfur-containing polycyclic aromatic compounds (S-PACs)) with 4-7 rings, as well as fraction containing more polar polycyclic aromatic compounds (PACs) and PAHs with higher molecular weight, induced lung carcinomas and sarcomas. According to probit analysis, the fraction containing PAHs plus S-PACs with 4-7 rings accounted for about 68.2% of the total carcinogenicity of flue gas condensate, whereas the fraction containing more polar PACs and higher PAHs accounted for about 54.6%. All other fractions, such as nonaromatic compounds and PACs with 2 and 3 rings, constituting about 70% of the weight of the total condensate, seemed not to be carcinogenic. Only 1.4% of the total carcinogenicity of the flue gas condensate was found to be attributable to the amount of benzo(a)pyrene (CAS: 50-32-8) present in the condensate (1.14 mg/g condensate). The contribution of more than 100% of both active fractions to the total carcinogenicity (68.2 and 54.6%) may suggest an interrelation of the fractions.
- Research Organization:
- Biochemical Institute for Environmental Carcinogens, Grosshansdorf, Germany, F.R.
- OSTI ID:
- 6391975
- Journal Information:
- J. Natl. Cancer Inst.; (United States), Vol. 5
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BENZOPYRENE
CARCINOGEN SCREENING
FLUE GAS
TOXICITY
LUNGS
CARCINOMAS
SARCOMAS
POLYCYCLIC AROMATIC HYDROCARBONS
AIR POLLUTION
CARCINOGENS
COAL
DOSE-RESPONSE RELATIONSHIPS
RATS
ANIMALS
AROMATICS
BODY
CARBONACEOUS MATERIALS
CONDENSED AROMATICS
DISEASES
ENERGY SOURCES
FOSSIL FUELS
FUELS
GASEOUS WASTES
HYDROCARBONS
MAMMALS
MATERIALS
NEOPLASMS
ORGANIC COMPOUNDS
ORGANS
POLLUTION
RESPIRATORY SYSTEM
RODENTS
SCREENING
VERTEBRATES
WASTES
016000* - Coal
Lignite
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560300 - Chemicals Metabolism & Toxicology