Local dose to lung tissue from inhaled /sup 238/PuO/sub 2/ particles. [Hamsters]

Journal Article · Tue Aug 01 04:00:00 EDT 1978 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3574910· OSTI ID:6391185

Diel, J H

A new method for computation of local dose to tissue from an alpha-emitting particle in deep lung is described. Syrian hamsters were exposed via inhalation to a monodisperse aerosol of 0.2 ..mu..m real diameter /sup 238/PuO/sub 2/ particles. At 8 to 35 days after exposure the animals were sacrificed, the lungs were inflated and fixed in situ, excised, paraffin embedded, sectioned at 5 ..mu..m thickness and autoradiographs were prepared. Particles were chosen at random from these autoradiographs and the location of the particle and configuration of the tissue surrounding the particle were input to a computer. Local dose rate and fraction of alpha particles which penetrate to or pass through tissue at a given distance from the source were computed. The local dose rate was used to compute the ''effect'' of this radiation pattern based on four empirical formulae. The average effects obtained were similar to those calculated assuming a structureless lung of uniform density 0.2 g/cm/sup 3/, but different from calculated effects based on uniform dose over the irradiated region. Under the dose effect assumptions used, the tumor induction probability per alpha disintegration of a /sup 238/PuO/sub 2/ particle in deep lung is inversely related to the activity of the particle.

• Research Organization: Lovelace Biomedical and Environmental Research Inst., Albuquerque, NM
• OSTI ID: 6391185
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 75:2; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560162* -- Radionuclide Effects
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE COMPOUNDS
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
AEROSOLS
ALPHA DECAY RADIOISOTOPES
ALPHA PARTICLES
ANIMALS
BODY
CHALCOGENIDES
CHARGED PARTICLES
COLLOIDS
DISPERSIONS
DOSE RATES
DOSES
DOSIMETRY
EVEN-EVEN NUCLEI
HAMSTERS
HEAVY NUCLEI
INHALATION
INTAKE
ISOTOPES
LUNGS
MAMMALS
NUCLEI
ORGANS
OXIDES
OXYGEN COMPOUNDS
PLUTONIUM 238
PLUTONIUM COMPOUNDS
PLUTONIUM ISOTOPES
PLUTONIUM OXIDES
RADIATION DOSES
RADIOACTIVE AEROSOLS
RADIOISOTOPES
RESPIRATORY SYSTEM
RODENTS
SOLS
TRANSURANIUM COMPOUNDS
VERTEBRATES
YEARS LIVING RADIOISOTOPES