Radiation-induced oxidation of benzo(a)pyrene. [Gamma radiation]
The oxidation in air of benzo(a)pyrene induced by /sup 60/Co ..gamma.. radiation gave over two dozen products, of which half have been identified. Products include three isomeric 7,8,9,10-tetrahydrobenzo(a)pyrene-7,8,9,10-tetraols, 9,10-dihydrobenzo(a)pyrene-trans-9,10-diol, a 7,8-dihydrobenzo(a)pyrene-7,8-diol, a 4,5-dihydrobenzo(a)pyrene-4,5-diol, benzo(a)pyrene-1,6-dione, benzo(a)pyrene-3.6-dione, benzo(a)pyrene-6,12-dione, 9-(2'formylphenyl)phenalen-1-one, and tentatively benzo(a)pyrene-3-ol, and benzo(a)pyren-9-ol. These results establish that air oxidation of benzo(a)pyrene yields products similar to those found as mammalian metabolites with oxidative attack at the K region, bay region, and the 6 position. Some of the air oxidation products are weakly mutagenic toward Salmonella typhimurium test strains.
- Research Organization:
- Univ. of Texas Medical Branch, Galveston
- OSTI ID:
- 6388077
- Journal Information:
- J. Org. Chem.; (United States), Journal Name: J. Org. Chem.; (United States) Vol. 44:11; ISSN JOCEA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Fungal oxidation of (+-)-9,10-dihydroxy-9,10-dihydrobenzo(a)pyrene: formation of diastereomeric benzo(a)pyrene 9,10-diol 7,8-epoxides
Specificity of chemiluminescence in the metabolism of benzo(a)pyrene to its carcinogenic diol epoxide
Related Subjects
400600* -- Radiation Chemistry
500200 -- Environment
Atmospheric-- Chemicals Monitoring & Transport-- (-1989)
54 ENVIRONMENTAL SCIENCES
AIR
ANIMALS
AROMATICS
BENZOPYRENE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CHEMICAL RADIATION EFFECTS
CHEMICAL REACTIONS
CHEMISTRY
COBALT 60
COBALT ISOTOPES
CONDENSED AROMATICS
ELECTROMAGNETIC RADIATION
FLUIDS
GAMMA RADIATION
GASES
HYDROCARBONS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
METABOLITES
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
OXIDATION
RADIATION CHEMISTRY
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
VERTEBRATES
YEARS LIVING RADIOISOTOPES